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329600

Sigma-Aldrich

Erastin

≥98% (HPLC), solid, ferroptosis inducer, Calbiochem®

Sinônimo(s):

Erastin, 2-(1-(4-(2-(4-Chlorophenoxy)acetyl)-piperazin-1-yl)-ethyl)-3-(2-ethoxyphenyl)-3H-quinazolin-4-one

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About This Item

Fórmula empírica (Notação de Hill):
C30H31ClN4O4
Número CAS:
571203-78-6
Peso molecular:
547.04
Número MDL:
MFCD09837984
Código UNSPSC:
12352200
NACRES:
NA.77
Preço e disponibilidade não estão disponíveis no momento.

Nome do produto

Erastin, A cell-permeable piperazinyl-quinazolinone compound that exhibits oncogene-selective lethality.

Nível de qualidade

100

Ensaio

≥98% (HPLC)

Formulário

solid

fabricante/nome comercial

Calbiochem®

condição de armazenamento

OK to freeze
protect from light

cor

white

solubilidade

DMSO: 50 mg/mL

Condições de expedição

wet ice

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

Clc1ccc(cc1)OCC(=O)N2CCN(CC2)C(C)c3[n]([c](c5c(n3)cccc5)=O)c4c(cccc4)OCC

InChI

1S/C30H31ClN4O4/c1-3-38-27-11-7-6-10-26(27)35-29(32-25-9-5-4-8-24(25)30(35)37)21(2)33-16-18-34(19-17-33)28(36)20-39-23-14-12-22(31)13-15-23/h4-15,21H,3,16-20H2,1-2H3

chave InChI

BKQFRNYHFIQEKN-UHFFFAOYSA-N

Descrição geral

A cell-permeable piperazinyl-quinazolinone compound that exhibits oncogene-selective lethality. Shown to bind mitochondrial voltage-dependent anion channels (VDAC) and alter its gating; rapidly induce an oxidative, non-apoptotic cell death in several human tumors harboring activating mutations in the RAS-RAF-MEK signaling (EC50 = 6.0 µM in BJ-TERT/LT/ST/RASV12 cells).

Embalagem

Packaged under inert gas

Advertência

Toxicity: Standard Handling (A)

Reconstituição

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Outras notas

Yagoda, N., et al. 2007. Nature447, 864.

Informações legais

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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