324385

Doxycycline, Hyclate

A commonly-used broad-spectrum antibiotic.

• Sinônimo(s): Doxycycline, Hyclate, α-6-Deoxy-5-hydroxytetracycline, Vibramycin, Hyclate
• Fórmula empírica (Notação de Hill): C₂₂H₂₄N₂O₈ · 0.5H₂O · 0.5C₂H₆O · xHCl
• Número CAS: 24390-14-5
• Peso molecular: 476.48 (free base basis)
• Número MDL: MFCD07357237
• Código UNSPSC: 12352200
• NACRES: NA.77

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥98% (HPLC)
• Formulário: crystalline solid
• fabricante/nome comercial: Calbiochem^®
• condição de armazenamento: OK to freeze; desiccated (hygroscopic)
• cor: yellow to yellow-green
• solubilidade: water: 50 mg/mL
• Condições de expedição: ambient
• temperatura de armazenamento: 2-8°C
• InChI: 1S/2C22H24N2O8.C2H6O.2ClH.H2O/c2*1-7-8-5-4-6-9(25)11(8)16(26)12-10(7)17(27)14-15(24(2)3)18(28)13(21(23)31)20(30)22(14,32)19(12)29;1-2-3;;;/h2*4-7,10,14-15,17,25-27,31-32H,23H2,1-3H3;3H,2H2,1H3;2*1H;1H2/b2*21-13+;;;;/t2*7-,10+,14+,15-,17-,22-;;;;/m00..../s1
• chave InChI: QDDHZFKCHWYXJF-PCLMCNLLSA-N

Descrição

Descrição geral

A commonly used broad-spectrum antibiotic. A potent inhibitor of MMP-8 (neutrophil collagenase; IC₅₀ = 30 µM) relative to MMP-1 (collagenase-1; IC₅₀ = 300 µM). Also inhibits collagen synthesis by bovine articular chondrocytes cultured in alginate (IC₅₀ = 25 µM). Inhibits nitric oxide synthesis by LPS-activated macrophages without affecting IL-10 release.

A commonly-used broad-spectrum antibiotic. A potent inhibitor of MMP-8 (neutrophil collagenase; IC₅₀ = 30 µM) relative to MMP-1 (interstitial collagenase; IC₅₀ = 300 µM). Also inhibits collagen synthesis by bovine articular chondrocytes cultured in alginate (IC₅₀ = 25 µM). Inhibits nitric oxide synthesis by LPS-activated macrophages without affecting IL-10 release.

Ações bioquímicas/fisiológicas

Cell permeable: no

Primary Target
MMP-8

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 30 µM against MMP-8 (neutrophil collagenase); 25 µM inhibiting collagen synthesis by bovine articular chondrocytes cultured in alginate

Advertência

Toxicity: Harmful & Carcinogenic / Teratogenic (E)

Reconstituição

Follwing reconstitution, refrigerate (4°C). Stock solutions are stable for up to 5 days at 4°C.

Outras notas

D’Agostino, P., et al. 1998. J. Infect. Dis. 177, 489.
Beekman, B., et al. 1997. Biochem. Biophys. Res. Commun. 237, 107.
Hanemaaijer, R., et al. 1997. J. Biol. Chem. 272, 31504.
Lauhio, A., et al. 1994. Clin. Exp. Immunol. Antimicrobiol. Agents Chemother. 36, 227.
Sorsa, T., et al. 1994. Ann. N.Y. Acad. Sci.732, 112.
Suomalainen, K., et al. 1992. Antimicrobiol. Agents Chemother.36, 227.

Informações legais

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Pictogramas: GHS08,GHS07
• Palavra indicadora: Warning
• Frases de perigo: H302,H315,H319,H335,H361fd,H412
• Declarações de precaução: P202 - P273 - P301 + P312 - P302 + P352 - P305 + P351 + P338 - P308 + P313
• Classificações de perigo: Acute Tox. 4 Oral - Aquatic Chronic 3 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT SE 3
• Órgãos-alvo: Respiratory system
• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable