215921

Chlorpromazine, Hydrochloride

Inhibits calmodulin-dependent stimulation of cyclic nucleotide phosphodiesterase (IC₅₀ = 17 µM).

• Sinônimo(s): Chlorpromazine, Hydrochloride
• Fórmula empírica (Notação de Hill): C₁₇H₁₉ClN₂S · xHCl
• Número CAS: 69-09-0
• Peso molecular: 318.86 (free base basis)
• Número MDL: MFCD00012654
• Código UNSPSC: 12352200
• NACRES: NA.77

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥99% (HPLC)
• forma: crystalline solid
• fabricante/nome comercial: Calbiochem^®
• condição de armazenamento: OK to freeze; desiccated (hygroscopic)
• cor: off-white
• solubilidade: methanol: 10 mg/mL; water: 50 mg/mL
• traços de ânion: sulfate (SO₄^2-): ≤0.05%
• traços de cátion: Fe: ≤0.001%; heavy metals: ≤0.002%
• Condições de expedição: ambient
• temperatura de armazenamento: 10-30°C
• InChI: 1S/C17H19ClN2S.ClH/c1-19(2)10-5-11-20-14-6-3-4-7-16(14)21-17-9-8-13(18)12-15(17)20;/h3-4,6-9,12H,5,10-11H2,1-2H3;1H
• chave InChI: FBSMERQALIEGJT-UHFFFAOYSA-N

Descrição

Descrição geral

Inhibits calmodulin-dependent stimulation of cyclic nucleotide phosphodiesterase (IC₅₀ = 17 µM).

Inhibits calmodulin-dependent stimulation of cyclic nucleotide phosphodiesterase (IC₅₀ = 17 µM). Acts as a peripheral vasodilator. Acts as an inhibitor of lysosomal sphingomyelinase and of TNF-α production. Inhibits nitric oxide synthase (NOS) in mouse brain and prevents lipopolysaccharide induction of NOS in murine lung. Shown to potently and specifically inhibit KSP/Eg5 (IC₅₀<10 µM), and PLA2.

Inhibits calmodulin-dependent stimulation of cyclic nucleotide phosphodiesterase (IC₅₀ = 17 µM). Acts as a peripheral vasodilator. An inhibitor of TNFα production. Inhibits nitric oxide synthase (NOS) in mouse brain and prevents lipopolysaccharide induction of NOS in murine lung. Shown to potently and specifically inhibit KSP/Eg5 (IC₅₀<10 µM), and PLA2.

Ações bioquímicas/fisiológicas

Primary Target
Calmodulin-dependent stimulation of cyclic nucleotide phosphodiesterase

Product does not compete with ATP.

Target IC₅₀: 17 µM inhibiting calmodulin-dependent stimulation of cyclic nucleotide phosphodiesterase

Advertência

Toxicity: Toxic (F)

Reconstituição

Following reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 6 months at -20°C and for up to 1 week at 4°C.

Outras notas

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Lee, M.S., et al. 2007. Cancer Res.67, 11359.
Maor, I., et al. 1995. Arteriosclero. Thromb. Vasc. Biol. 15, 1378.
Netea, M.G., et al. 1995. J. Infect. Dis. 171, 393.
Lindahl, M., and Tagesson, C. 1993. Inflammation17, 573.
Palacios, M., et al. 1993. Biochem. Biophys. Res. Commun. 196, 280.
Yamamoto, H. 1993. Toxicol. Lett. 66, 73.
Vadas, P., et al. 1986. Agents Actions19, 194.
Marshak, P.R., et al. 1985. Biochemistry24, 144.

Informações legais

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Pictogramas: GHS06
• Palavra indicadora: Danger
• Frases de perigo: H301,H330
• Declarações de precaução: P260 - P264 - P270 - P271 - P284 - P304 + P340 + P310
• Classificações de perigo: Acute Tox. 1 Inhalation - Acute Tox. 3 Oral
• Código de classe de armazenamento: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable