Following reconstitution in DMSO, it is recommended to aliquot and freeze stock solutions at -20°C for up to 1 month. The solution stability at -80°C has not been determined for this product.
203391
(-)-Blebbistatin
≥98% (HPLC), solid, ATPase inhibitor, Calbiochem®
Sinônimo(s):
(-)-Blebbistatin
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About This Item
Fórmula empírica (Notação de Hill):
C18H16N2O2
Número CAS:
Peso molecular:
292.33
Número MDL:
Código UNSPSC:
12352200
NACRES:
NA.77
Preço e disponibilidade não estão disponíveis no momento.
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Nome do produto
(-)-Blebbistatin, The active enantiomer of (±)-Blebbistatin that accounts for the inhibitory activity towards ATPase and myosin II-dependent cellular processes.
Nível de qualidade
Ensaio
≥98% (HPLC)
Formulário
solid
potência
2 μM IC50
fabricante/nome comercial
Calbiochem®
condição de armazenamento
OK to freeze
protect from light
cor
yellow
solubilidade
methanol: 1.5 mg/mL
100% DMSO: 100 mg/mL
90% DMSO: 75 mg/mL
Condições de expedição
wet ice
temperatura de armazenamento
−20°C
cadeia de caracteres SMILES
N2(CC[C@@]3(C2=Nc4c(cc(cc4)C)C3=O)O)c1ccccc1
InChI
1S/C18H16N2O2/c1-12-7-8-15-14(11-12)16(21)18(22)9-10-20(17(18)19-15)13-5-3-2-4-6-13/h2-8,11,22H,9-10H2,1H3/t18-/m1/s1
chave InChI
LZAXPYOBKSJSEX-GOSISDBHSA-N
Descrição geral
The active enantiomer of (±)-Blebbistatin (Cat. No. 203390) that accounts for the inhibitory activity towards ATPase (IC50 = ~2 µM) and myosin II-dependent cellular processes. Also reported to potently inhibit the actomyosin ATPase activities of expressed smooth muscle myosin IIA (SMA) and smooth muscle myosin IIB (SMB) smooth muscle myosin II heavy-chain isoforms (IC50 ~3 µM).
Ações bioquímicas/fisiológicas
Cell permeable: yes
Product does not compete with ATP.
Reversible: yes
Embalagem
Packaged under inert gas
Advertência
Toxicity: Harmful & Carcinogenic / Teratogenic (E)
Reconstituição
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month in 90% DMSO or methanol (-20°C). Stock solutions in 100% DMSO are unstable; reconstitute just prior to use.
Outras notas
Eddinger, T.J. et al. 2007. J. Pharmacol. Exp. Ther.320, 865.
Shu, S., et al. 2005. Proc. Natl. Acad. Sci. USA102, 1472.
Kovacs, M., et al. 2004. J. Biol. Chem.279, 35557.
Straight, A.F., et al. 2003. Science299, 1743.
Shu, S., et al. 2005. Proc. Natl. Acad. Sci. USA102, 1472.
Kovacs, M., et al. 2004. J. Biol. Chem.279, 35557.
Straight, A.F., et al. 2003. Science299, 1743.
Informações legais
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 3
Certificados de análise (COA)
Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.
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Can this be stored in -80 once in 90%DMSO?
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