19-148
Bafilomycin A1
Sinônimo(s):
Bafilomycin A
Faça loginpara ver os preços organizacionais e de contrato
About This Item
Código UNSPSC:
12352106
eCl@ss:
32160405
NACRES:
NA.41
Produtos recomendados
descrição
Bafilomycin A1 is a specific potent inhibitor of vacuolar-type H+-ATPases, and blocks lysosomal cholesterol transport in macrophages.
Nível de qualidade
fabricante/nome comercial
Upstate®
técnica(s)
activity assay: suitable (kinase)
temperatura de armazenamento
−20°C
Aplicação
Bafilomycin A1 has been used:
- as an autophagy inhibitor to study its effect on traumatic brain injury (TBI)-induced cell death and lesions in mice
- to treat neurons for pH luorin assays to measure endocytosis during synaptic activity
- to block autophagy in mouse embryonic fibroblasts
Ações bioquímicas/fisiológicas
Inhibitor Type: Kinase
forma física
C35H58O9
Armazenamento e estabilidade
3 years at -20°C
Informações legais
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Exoneração de responsabilidade
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 3
Certificados de análise (COA)
Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.
Já possui este produto?
Encontre a documentação dos produtos que você adquiriu recentemente na biblioteca de documentos.
Os clientes também visualizaram
Wenchang Xiao et al.
Signal transduction and targeted therapy, 6(1), 152-152 (2021-04-17)
Autophagy is the main degradation pathway to eliminate long-lived and aggregated proteins, aged or malfunctioning organelles, which is essential for the intracellular homeostasis and prevention of malignant transformation. Although the processes of autophagosome biogenesis have been well illuminated, the mechanism
Seongju Lee et al.
International journal of molecular sciences, 21(21) (2020-11-01)
Keloid is a representative chronic fibroproliferative condition that occurs after tissue injury. Emerging evidence showed that activation of NACHT, LRR, and PYD domains-containing protein 3 (NLRP3) inflammasome is involved in the pro-inflammatory response in injured tissues. However, the role of
Jianzhong Li et al.
Frontiers in cell and developmental biology, 8, 576988-576988 (2020-12-15)
Bixin, a natural carotenoid extracted from the seeds of Bixa orellana, has antioxidant and anti-inflammation effects. However, the pharmacological effects and underlying mechanisms of bixin in kidney interstitial fibrosis remain unknown. Partial epithelial-to-mesenchymal transition (EMT) of tubular cells has been
Hereditary spastic paraplegia SPG8 mutations impair CAV1-dependent, integrin-mediated cell adhesion.
Seongju Lee et al.
Science signaling, 13(613) (2020-01-09)
Mutations in WASHC5 (also known as KIAA0196) cause autosomal dominant hereditary spastic paraplegia (HSP) type SPG8. WASHC5, commonly called strumpellin, is a core component of the Wiskott-Aldrich syndrome protein and SCAR homolog (WASH) complex that activates actin nucleation at endosomes.
Zongyi Hu et al.
Cell chemical biology, 27(7), 780-792 (2020-05-11)
Chlorcyclizine (CCZ) is a potent hepatitis C virus (HCV) entry inhibitor, but its molecular mechanism is unknown. Here, we show that CCZ directly targets the fusion peptide of HCV E1 and interferes with the fusion process. Generation of CCZ resistance-associated
Nossa equipe de cientistas tem experiência em todas as áreas de pesquisa, incluindo Life Sciences, ciência de materiais, síntese química, cromatografia, química analítica e muitas outras.
Entre em contato com a assistência técnica