1.20091

Sílica

EMPROVE^® ESSENTIAL, Ph. Eur., NF

• Sinônimo(s): Dióxido de silício
• Fórmula linear: SiO₂
• Número CAS: 7631-86-9
• Peso molecular: 60.08
• Número MDL: MFCD00011232
• Código UNSPSC: 12352201

Propriedades

• Agency: NF; Ph. Eur.
• Nível de qualidade: 500
• linha de produto: EMPROVE^® ESSENTIAL
• Formulário: fine powder
• tamanho de partícula: 17-25 μm (d50)
• p.e.: 2230 °C (lit.)
• pf: >1600 °C (lit.); 1710 °C
• aplicação(ões): pharmaceutical; pharmaceutical; solid formulation; solubility enhancement
• temperatura de armazenamento: 2-30°C
• cadeia de caracteres SMILES: O=[Si]=O
• InChI: 1S/O2Si/c1-3-2
• chave InChI: VYPSYNLAJGMNEJ-UHFFFAOYSA-N

Descrição

Descrição geral

With formulation challenges in mind, we have used particle engineering technologies to develop functional excipients specifically for solid dosage forms. The products in our Parteck^® portfolio feature unique particle properties tailored for excellent performance in tableting processes, for specific drug delivery technologies, or for solubility enhancement. Our SAFC^® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Aplicação

Parteck^® SLC excipient is an innovative silica drug carrier that enhances drug solubility thanks to its unique surface structure, which can stabilize the amorphous state. This is especially relevant for poor glass forming APIs, which can be difficult to stabilize with other formulation technologies. Parteck^® SLC is also emerging as a first-in-class excipient to reduce the risk of unstable polymorphism and particle properties in drug development. In this application, Parteck^® SLC can homogenize both properties in a template-based formulation approach, with robust and reliable results.

Características e benefícios

• Solubility enhancement of APIs
• Unparalleled stabilization of the amorphous solid state
• Unique pore structure (6 nm diameter) and a very high surface area (500 m²/g)
• Perfect fit to stabilize poor glass former molecules
• Platform approach to manage API particle and polymorph variation
• No specific equipment/extra capital invest needed to stabilize the amorphous form of APIs
• High-end application support

Embalagem

1200910300 // Wide necked plastic bottle in corrugated box
1200911000 // Wide necked plastic bottle in corrugated box
1200919025 // Standard PE bag in PE square drum

Informações legais

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

PARTECK is a registered trademark of Merck KGaA, Darmstadt, Germany

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Código de classe de armazenamento: 13 - Non Combustible Solids
• Classe de risco de água (WGK): nwg
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable