09-818
Anti-CARM1 Antibody
from rabbit
Sinônimo(s):
Protein arginine N-methyltransferase 4, coactivator-associated arginine methyltransferase 1, coactivator-associated arginine methyltransferase-1
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About This Item
Código UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Produtos recomendados
fonte biológica
rabbit
Nível de qualidade
forma do anticorpo
affinity isolated antibody
tipo de produto de anticorpo
primary antibodies
clone
polyclonal
reatividade de espécies
rat, human
reatividade da espécie (prevista por homologia)
mouse
técnica(s)
western blot: suitable
nº de adesão NCBI
nº de adesão UniProt
Condições de expedição
wet ice
modificação pós-traducional do alvo
unmodified
Informações sobre genes
human ... CARM1(10498)
mouse ... Carm1(59035)
Descrição geral
CARM1 (coactivator-associated arginine methyltransferase 1) is an arginine N-methyltransferase that catalyzes the transfer of a methyl group from S-adenosyl-L-methionine to arginine residues within proteins. CARM1 targets include methylation of histone H3 at Arg17 and p300 at Arg2142. CARM1 is recruited to promoters upon gene activation together with histone acetyltransferases from the p300 and p160 families. During monocyte inflammatory stimulation, CARM1 acts together with p300 as a coactivator for NF-kB. It is responsible for moving cells toward the inner cell mass in developing blastocysts. CARM1 also plays an important role in androgen receptors and may play a role in prostate cancer progression.
Especificidade
Recognizes CARM1, Mr ~60 kDa.
Imunogênio
Epitope: a.a. 595-608
KLH-conjugated, synthetic peptide containing the sequence (CSPMSIPTNTMHYGS), corresponding to a.a. 595-608 of human CARM1.
Aplicação
Anti-CARM1 Antibody is a rabbit polyclonal antibody for detection of CARM1 also known as Protein arginine N-methyltransferase 4, coactivator-associated arginine methyltransferase 1 & has been validated in WB.
Western Blot Analysis:
A 1 μg/mL dilution of this lot detected CARM1 in HeLa nuclear extracts. (Figure A).
A 1 μg/mL dilution of this lot detected CARM1 in HeLa nuclear extracts. (Figure A).
Descrição-alvo
~60 kDa
forma física
Format: Purified
Purified by peptide affinity chromatography. Supplied at 1 mg/ml in 0.1 M Tris-Glycine (pH7.4) 15 mM NaCl, 0.05% sodium azide.
Nota de análise
Control
Included Positive Antigen Control: Catalog # 12-309, HeLa nuclear extract. Add an equal volume of Laemmli reducing sample buffer to 10 μL of lysate and boil for 5 minutes to reduce the preparation. Load 20 μg of reduced lysate per lane for minigels.
Included Positive Antigen Control: Catalog # 12-309, HeLa nuclear extract. Add an equal volume of Laemmli reducing sample buffer to 10 μL of lysate and boil for 5 minutes to reduce the preparation. Load 20 μg of reduced lysate per lane for minigels.
Outras notas
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
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Código de classe de armazenamento
12 - Non Combustible Liquids
Classe de risco de água (WGK)
WGK 1
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Certificados de análise (COA)
Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.
Já possui este produto?
Encontre a documentação dos produtos que você adquiriu recentemente na biblioteca de documentos.
Maria-Elena Torres-Padilla et al.
Nature, 445(7124), 214-218 (2007-01-12)
It has been generally accepted that the mammalian embryo starts its development with all cells identical, and only when inside and outside cells form do differences between cells first emerge. However, recent findings show that cells in the mouse embryo
Heng Hong et al.
Cancer, 101(1), 83-89 (2004-06-29)
Coactivator-associated arginine methyltransferase 1 (CARM1) is a transcriptional coactivator of the androgen receptor (AR). It is involved in the regulation of the biologic functions of the AR. It remains to be determined whether CARM1 is involved in prostatic carcinogenesis. The
D Chen et al.
Science (New York, N.Y.), 284(5423), 2174-2177 (1999-06-26)
The p160 family of coactivators, SRC-1, GRIP1/TIF2, and p/CIP, mediate transcriptional activation by nuclear hormone receptors. Coactivator-associated arginine methyltransferase 1 (CARM1), a previously unidentified protein that binds to the carboxyl-terminal region of p160 coactivators, enhanced transcriptional activation by nuclear receptors
Cynthia M Quintero et al.
Journal of molecular biology, 430(21), 4168-4182 (2018-08-29)
Activation of the retinoic acid (RA) signaling pathway is important for controlling embryonic stem cell differentiation and development. Modulation of this pathway occurs through the recruitment of different epigenetic regulators at the retinoic acid receptors (RARs) located at RA-responsive elements
The expression of myogenic microRNAs indirectly requires protein arginine methyltransferase (Prmt)5 but directly requires Prmt4.
Mallappa, C; Hu, YJ; Shamulailatpam, P; Tae, S; Sif, S; Imbalzano, AN
Nucleic Acids Research null
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