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D-907

Supelco

Diazepam solution

1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

Fórmula empírica (Notação de Hill):
C16H13ClN2O
Número CAS:
439-14-5
Peso molecular:
284.74
Número CE:
200-659-6
Número MDL:
MFCD00057323
Código UNSPSC:
41116107
ID de substância PubChem:
329798890
NACRES:
NA.24
Preço e disponibilidade não estão disponíveis no momento.

grau

certified reference material

Nível de qualidade

300

Formulário

liquid

Características

Snap-N-Spike®/Snap-N-Shoot®

embalagem

ampule of 1 mL

fabricante/nome comercial

Cerilliant®

drug control

Narcotic Licence Schedule B (Switzerland); psicótropo (Spain); Decreto Lei 15/93: Tabela IV (Portugal)

concentração

1.0 mg/mL in methanol

técnica(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

aplicação(ões)

clinical testing

Formato

single component solution

temperatura de armazenamento

-10 to -25°C

cadeia de caracteres SMILES

CN1C(=O)CN=C(c2ccccc2)c3cc(Cl)ccc13

InChI

1S/C16H13ClN2O/c1-19-14-8-7-12(17)9-13(14)16(18-10-15(19)20)11-5-3-2-4-6-11/h2-9H,10H2,1H3

chave InChI

AAOVKJBEBIDNHE-UHFFFAOYSA-N

Informações sobre genes

human ... GABRA1(2554) , GABRA2(2555) , GABRA3(2556) , GABRA4(2557) , GABRA5(2558) , GABRA6(2559) , GABRB1(2560) , GABRB2(2561) , GABRB3(2562) , GABRD(2563) , GABRE(2564) , GABRG1(2565) , GABRG2(2566) , GABRG3(2567) , GABRP(2568) , GABRQ(55879)

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Descrição geral

This Certified Spiking Solution® is suitable for testing diazepam by HPLC, GC/MS or LC-MS/MS methods in forensic analysis, clinical toxicology, urine drug testing, and cannabis potency or impurity profiling testing applications.

Diazepam is an anxiolytic benzodiazepine drug, commonly used to treat anxiety disorders, muscle spasms, and acute seizures among others.

Aplicação

The Certified Reference Material (CRM) in solution can also be used as follows:
  • Electrochemical determination of diazepam in serum, urine, and tablet formulations by a modified electrode based on fullerene-functionalized carbon nanotubes and ionic liquid (C60-CNTs/IL)[1]
  • Differential voltametric analysis of diazepam in its tablet formulations and human urine samples using a bismuth-modified pre-treated pencil graphite electrode (BiPPGE)[2]
  • Simultaneous quantitative determination of diazepam and flunitrazepam in alcoholic beverage samples by Direct-electron ionization-liquid chromatography-tandem mass spectrometry (EI-LC-MS/MS) method
  • Dispersive nanomaterial-ultrasound assisted-microextraction (DNUM) of diazepam and chlordiazepoxide from urine and plasma samples for their quantification by high-performance liquid chromatography -UV (HPLC-UV) detection[3]
  • Multi-residue analysis of diazepam and its metabolites in human oral fluid samples by their solid-phase extraction followed by LC-MS/MS method-based determination

Características e benefícios

  • Fully characterized under ISO/IEC 17025 and ISO 17034 accreditation
  • Accompanied with a comprehensive Certificate of Analysis (CoA) with data on stability, homogeneity, accuracy of concentration, uncertainty, and traceability
  • Rigorously tested through real-time stability studies to ensure accuracy and shelf life
  • Gravimetrically prepared using qualified precision balances to ensure minimal uncertainty
  • Flame sealed under argon into ampoules for long-term shelf life
  • Offered in a convenient, DEA-exempt format to improve laboratory efficiency

Informações legais

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

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Palavra indicadora

Danger

Classificações de perigo

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Órgãos-alvo

Eyes,Central nervous system

Código de classe de armazenamento

3 - Flammable liquids

Classe de risco de água (WGK)

WGK 2

Ponto de fulgor (°F)

49.5 °F - closed cup

Ponto de fulgor (°C)

9.7 °C - closed cup

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Electrochemical determination of diazepam in real samples based on fullerene-functionalized carbon nanotubes/ionic liquid nanocomposite
Rahimi-Nasrabadi M, et al.
Sensors and Actuators B, Chemical, 240, 125-131 (2017)
Voltammetric determination of diazepam using a bismuth modified pencil graphite electrode
Dehghanzade M and Alipour E
Analytical Methods : Advancing Methods and Applications, 8, 1995-2004 (2016)
A Amiri Pebdani et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1008, 146-155 (2015-12-15)
Benzodiazepines (BDs) are used widely in clinical practice, due to their multiple pharmacological functions. In this study a dispersive nanomaterial-ultrasound assisted- microextraction (DNUM) method followed by high performance liquid chromatography (HPLC) was used for the preconcentration and determination of chlordiazepoxide
Berend Malchow et al.
Journal of neural transmission (Vienna, Austria : 1996), 122(7), 1019-1033 (2014-10-14)
Hippocampus volumes have been shown to be decreased in patients with major depression, but volume measurements are inconsistent in patients with bipolar disorder. Both disorders are associated with deficits in hippocampus-mediated cognitive functions. However, the underlying pathophysiology is widely unknown.
Haim Bassan et al.
Epilepsia, 54(6), 1092-1098 (2013-04-05)
Prolonged febrile seizures (PFS) lasting ≥15 min have been associated with increased risk for epilepsy in later life. Initial treatment, mostly prehospital, aims to prevent its evolution to febrile status epilepticus (FSE) and reduce adverse outcome. Paucity of information is
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