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850336P

Avanti

MAPCHO™-12

Avanti Research™ - A Croda Brand

Sinônimo(s):

DPC; Fos-Choline-12; FOS12; FC-12

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1 G
R$ 1.343,00
5 G
R$ 5.173,00
25 G
R$ 19.868,00

R$ 1.343,00

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1 G
R$ 1.343,00
5 G
R$ 5.173,00
25 G
R$ 19.868,00

About This Item

Fórmula empírica (Notação de Hill):
C17H38NO4P
Número CAS:
29557-51-5
Peso molecular:
351.46
Número MDL:
MFCD00674306
Código UNSPSC:
12352211
NACRES:
NA.25

R$ 1.343,00

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descrição

n-dodecylphosphocholine

Ensaio

>99% (TLC)

Formulário

powder

embalagem

pkg of 1 × 1 g (850336P-1g)
pkg of 1 × 25 g (850336P-25g)
pkg of 1 × 5 g (850336P-5g)

fabricante/nome comercial

Avanti Research™ - A Croda Brand

Condições de expedição

dry ice

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

[P](=O)([O-])(OCC[N+](C)(C)C)OCCCCCCCCCCCC

InChI

1S/C17H38NO4P/c1-5-6-7-8-9-10-11-12-13-14-16-21-23(19,20)22-17-15-18(2,3)4/h5-17H2,1-4H3

chave InChI

QBHFVMDLPTZDOI-UHFFFAOYSA-N

Descrição geral

Dodecylphosphocholine is a structural analog of lauroyl lysophosphatidylcholine that is more stable to hydrolytic degradation. The lipid is often used as a detergent for membrane protein solubilization and purification.Dodecylphosphocholine has been shown to improve paracellular permeability of hydrophilic compounds by modulating the tight junctions. This may have implications on its use for oral or nasal drug delivery.
MAPCHO™-12 or n-dodecylphosphocholine is a detergent with short chain.[1]

Aplicação

MAPCHO™-12 is suitable for use as detergent for B. subtilis cytochrome b558 protein for nuclear magnetic resonance experiments.[2] It is also suitable for use in the purification of cytoplasmic tail of gp41 (gp41CT) protein and micelle preparation.[3]

Ações bioquímicas/fisiológicas

MAPCHO™-12 or n-dodecylphosphocholine in combination with 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) is used for membrane-mimetic bicelle system for orientation based studies in membrane proteins.[1] It provides a zwitterionic surface in the membrane micelle structure.[4]

Embalagem

125 mL Amber Wide Mouth Glass Bottle with Screw Cap (850336P-5g)
20 mL Clear Glass Screw Cap Vial (850336P-1g)
250 mL Amber Wide Mouth Glass Bottle with Screw Cap (850336P-25g)

Informações legais

Avanti Research is a trademark of Avanti Polar Lipids, LLC
MAPCHO is a trademark of Avanti Polar Lipids, LLC

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

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Certificados de análise (COA)

Lot/Batch Number

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N,N-Dimetildodecilamina-N-óxido BioXtra, ≥99.0% (NT)

Sigma-Aldrich

40234

N,N-Dimetildodecilamina-N-óxido

1,2-Didodecanoyl-sn-glycero-3-phosphocholine ≥99%, synthetic

Sigma-Aldrich

P1263

1,2-Didodecanoyl-sn-glycero-3-phosphocholine

07:0 PC (DHPC) Avanti Research™ - A Croda Brand

Avanti

850306P

07:0 PC (DHPC)

06:0 PC (DHPC) Avanti Research™ - A Croda Brand

Avanti

850305P

06:0 PC (DHPC)

N,N-Dimetildodecilamina-N-óxido ~30% in H2O

Sigma-Aldrich

40236

N,N-Dimetildodecilamina-N-óxido

Nina Liu et al.
Heliyon, 5(12), e03018-e03018 (2020-01-01)
Fusion of host and viral membranes is a crucial step during infection by enveloped viruses. In the structurally-defined "class I″ viral glycoproteins, the formation of a highly stable α-helical bundle by the ectodomain of the fusion subunit (e.g., GP2 for
Magnetically oriented dodecylphosphocholine bicelles for solid-state NMR structure analysis
Nolandt OV, et al.
Biochimica et Biophysica Acta - Biomembranes, 1818(5), 1142-1147 (2012)
Roman Brunecky et al.
Biochemistry, 44(49), 16064-16071 (2005-12-08)
A growing number of modules including FYVE domains target key signaling proteins to membranes through specific recognition of lipid headgroups and hydrophobic insertion into bilayers. Despite the critical role of membrane insertion in the function of these modules, the structural
Pasquale Palladino et al.
Journal of fluorescence, 20(1), 191-196 (2009-09-17)
We have investigated the effect of ionic strength on the aggregation behavior of n-dodecyl phosphocholine. On the basis of the classical Corrin-Harkins relation, the critical micellar concentration of this detergent decreases with a biphasic trend on lithium chloride addition. It
N P Santisteban et al.
Biochimica et biophysica acta. Biomembranes, 1862(5), 183199-183199 (2020-01-29)
The lipid bilayer disrupting effect of antimicrobial peptides (AMPs) has been widely studied in model-lipid systems by applying biophysical techniques such as 2H NMR spectroscopy. Real bacteria cell envelopes contain non-lipid components, such as peptidoglycan, and thus it is important
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