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810251P

Avanti

NBD-6 Cholesterol

Avanti Research™ - A Croda Brand 810251P, powder

Sinônimo(s):

5-cholesten-3β-ol 6-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]caproate

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About This Item

Fórmula empírica (Notação de Hill):
C39H58N4O5
Número CAS:
201731-19-3
Peso molecular:
662.90
Número MDL:
MFCD03453619
Código UNSPSC:
12352211
NACRES:
NA.25

Ensaio

>99% (TLC)

Formulário

powder

embalagem

pkg of 1 × 1 mg (810251P-1mg)
pkg of 1 × 5 mg (810251P-5MG)

fabricante/nome comercial

Avanti Research™ - A Croda Brand 810251P

Condições de expedição

dry ice

temperatura de armazenamento

−20°C

Descrição geral

NBD-6 Cholesterol is a fluorescent analog of the lipoprotein compound cholesterol, with NBD (2-(4-nitro-2,1,3-benzoxadiazol-7-yl) aminoethyl) being the fluorescent group.

Aplicação

NBD-6 Cholesterol has been used for NBD-cholesterol binding assay, to study the binding of fluorescent NBD cholesterol in the binding pocket concerning ASTER domains.

Ações bioquímicas/fisiológicas

Cholesterol is produced from acetyl-CoA by a complex multistep mevalonate pathway. In mammals, liver is the main site of de novo cholesterol synthesis contributing to almost 80% of total cholesterol synthesis. Cholesterol and its metabolites, along with its precursors, play important roles in cellular membrane physiology. They also have roles in reproductive biology, dietary nutrient absorption, stress responses, salt and water balance and calcium metabolism.

Embalagem

5 mL Amber Glass Screw Cap Vial (810299P-1MG)
5 mL Amber Glass Screw Cap Vial (810251P-1mg)

Informações legais

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

No data available

Ponto de fulgor (°C)

No data available

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Certificados de análise (COA)

Lot/Batch Number

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Molecular Nutrition And Food Research, 277-290 (2016)
Fluorescent and Luminescent Probes for Biological Activity (1999)
Cholesterol in health and disease.
Ira Tabas
The Journal of clinical investigation, 110(5), 583-590 (2002-09-05)
Pedro M R Cruz et al.
Frontiers in pharmacology, 4, 119-119 (2013-10-05)
While the unique metabolic activities of malignant tissues as potential targets for cancer therapeutics has been the subject of several recent reviews, the role of cholesterol metabolism in this context is yet to be fully explored. Cholesterol is an essential
Jaspreet Sandhu et al.
Cell, 175(2), 514-529 (2018-09-18)
The mechanisms underlying sterol transport in mammalian cells are poorly understood. In particular, how cholesterol internalized from HDL is made available to the cell for storage or modification is unknown. Here, we describe three ER-resident proteins (Aster-A, -B, -C) that

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