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764787

Sigma-Aldrich

Poly(lactide-co-glycolide)-block-poly(ethylene glycol)-block-poly(lactide-co-glycolide)

average Mn (1,000-1,000-1,000), lactide:glycolide 50:50

Sinônimo(s):

PLGA-PEG-PLGA

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About This Item

Código UNSPSC:
12162002
NACRES:
NA.23

descrição

typical PEG PDI<1.1; overall PDI<1.2 (THF, PEO)

forma

liquid

proporção de alimentação

lactide:glycolide 50:50

peso molecular

PEG average Mn 1,000
PLGA average Mn 2000
average Mn (1,000-1,000-1,000)

prazo de degradação

1-2 weeks

PDI

<1.2

temperatura de armazenamento

2-8°C

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Descrição geral

PLGA-PEG-PLGA is an amphiphilic triblock copolymer which can self-assemble into micelles in aqueous medium due to the hydrophobic interactions present in the hydrophobic segments. The PEG segment imparts hydrophilicity and improves the biocompatibility of the copolymer. The PLGA segment forms a hydrophobic core and can solubilize hydrophobic drugs. These copolymers are widely used as nanocarriers for the sustained release of drugs.

Aplicação

Used in the synthesis of targeted nanoparticles which are used for differential delivery and controlled release of drugs.

Características e benefícios

Biocompatible, degradable, thermosensitive, high stability, small size (<200 nm) and properties can be easily modified.

Código de classe de armazenamento

10 - Combustible liquids

Classe de risco de água (WGK)

nwg

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

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Certificados de análise (COA)

Lot/Batch Number
MKCN7068
MKCG6095
MKCC8982
MKBX1132V
MKBT6439V

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Zhimei Song et al.
Journal of colloid and interface science, 354(1), 116-123 (2010-11-04)
The aim of this study was to assess the potential of new copolymeric micelles to modify the pharmacokenetics and tissue distribution of Curcumin (CUR), a hydrophobic drug. In the present study, a poly (d,l-lactide-co-glycolide)-b-poly(ethylene glycol)-b-poly(d,l-lactide-co-glycolide) (PLGA-PEG-PLGA) copolymer was synthesized and
PLGA-PEG Encapsulated sitamaquine nanoparticles drug delivery system against Leishmania donovani
Kumara, R., Sahoo, G. C., Pandeya, K., Dasa, V. N. R., Yousuf, M., Ansaria, S. R., &amp; Dasa, P.
Journal of Scientific and Innovative Research, 3(1), 85-90 (2014)
Frank Gu et al.
Proceedings of the National Academy of Sciences of the United States of America, 105(7), 2586-2591 (2008-02-15)
There has been progressively heightened interest in the development of targeted nanoparticles (NPs) for differential delivery and controlled release of drugs. Despite nearly three decades of research, approaches to reproducibly formulate targeted NPs with the optimal biophysicochemical properties have remained

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