765139

Poly(ethylene glycol) methyl ether-block-poly(lactide-co-glycolide)

PEG average M_n 5,000, PLGA M_n 7,000

• Sinônimo(s): PEG-PLGA, Polyethylene glycol, mPEG-b-PLGA
• Fórmula linear: H[(C₃H₄O₂)_x(C₂H₂O₂)_y]_mO[C₂H₄O]_nCH₃
• Código UNSPSC: 12162002
• NACRES: NA.23

Propriedades

• Formulário: solid
• Nível de qualidade: 100
• proporção de alimentação: lactide:glycolide 50:50
• peso molecular: PEG average M_n 5,000; PLGA M_n 7,000; average M_n 12,000 (total)
• prazo de degradação: 1-4 weeks
• temperatura de transição: T_g 24 °C; T_m 38-43 °C
• PDI: <2.0
• temperatura de armazenamento: 2-8°C

Descrição

Descrição geral

Amphiphilic block copolymers (AmBC) are made up of two chemically different homopolymer blocks. One of the block is hydrophilic and the other one is hydrophobic. These macromolecules have the properties to self-assemble when dissolved in an aqueous media. PEG-PLGA is one the most commonly used biodegradable amphiphilic block copolymers for drug delivery applications. PEG is the hydrophilic part and PLGA is the hydrophobic part.[1]

Aplicação

Used in the synthesis of targeted nanoparticles which are used for differential delivery and controlled release of drugs.[2][3]

forming "stealth" pegylated microparticles

Características e benefícios

• Good biocompatibility, low immunogenicity and good degradability.
• Properties can be easily modulated by changing the block copolymer segment sizes to suit a particular application. [1]

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): No data available
• Ponto de fulgor (°C): No data available