764205

Alkyne-PEG4-maleimide

90% (HPLC)

• Sinônimo(s): Acetylene-PEG4-maleimide
• Fórmula empírica (Notação de Hill): C₁₈H₂₆N₂O₇
• Peso molecular: 382.41
• Número MDL: MFCD22380740
• Código UNSPSC: 12352111
• ID de substância PubChem: 329767106
• NACRES: NA.22

Propriedades

• Ensaio: 90% (HPLC)
• Formulário: liquid
• adequação da reação: reaction type: click chemistry; reagent type: cross-linking reagent
• pf: 62-67 °C
• grupo funcional: alkyne; maleimide
• temperatura de armazenamento: −20°C
• cadeia de caracteres SMILES: O=C(N1CCC(NCCOCCOCCOCCOCC#C)=O)C=CC1=O
• InChI: 1S/C18H26N2O7/c1-2-8-24-10-12-26-14-15-27-13-11-25-9-6-19-16(21)5-7-20-17(22)3-4-18(20)23/h1,3-4H,5-15H2,(H,19,21)
• chave InChI: GHEBECZRHJXPTL-UHFFFAOYSA-N

Descrição

Aplicação

Alkyne-PEG4-maleimide has been used for modification of Csy containing bacterial collagens by introducing alkyne moiety to enable it for further chemical modification.[1]

Heterobifunctional crosslinker enabling the connection of an azide containing compound or biomolecule to one with a thiol. The maleimide group will react preferentially with thiols to form a covalent adduct and the terminal alkyne will react with azides via copper-catalyzed 1,3-dipolar cycloaddition click chemistry. The hydrophilic PEG spacer adds to the water solubility of this reagent, allowing for easy modification cysteine containing biomolecules such as antibodies, proteins and peptides with the terminal alkyne. The PEG spacer also reduces aggregation of modified proteins stored in solution by adding hydrophilic character.

Informações de segurança

• Código de classe de armazenamento: 10 - Combustible liquids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable