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70990

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αAcide α-cyano-4-hydroxycinnamique

matrix substance for MALDI-MS, ≥99.0% (HPLC)

Synonyme(s) :

αα-CCA, αα-CHCA, αα-Cyano, 4-HCCA, ACCA

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About This Item

Formule linéaire :
HOC6H4CH=C(CN)CO2H
Numéro CAS:
28166-41-8
Poids moléculaire :
189.17
Numéro Beilstein :
3271427
Numéro CE :
248-879-1
Numéro MDL:
MFCD00004204
Code UNSPSC :
12000000
ID de substance PubChem :
329762519
Nomenclature NACRES :
NA.21

Qualité

matrix substance for MALDI-MS

Niveau de qualité

100

Pureté

≥99.0% (HPLC)

Forme

solid

Classe(s) chimique(s) de l'analyte

glycans, peptides, proteins

Technique(s)

MALDI-MS: suitable

Pf

245-250 °C (lit.)
245-250 °C

Solubilité

methanol: 10 mg/mL, clear

Traces de cations

Ba: ≤5 mg/kg
Ca: ≤10 mg/kg
Cd: ≤5 mg/kg
Co: ≤5 mg/kg
Cr: ≤5 mg/kg
Cu: ≤5 mg/kg
K: ≤5 mg/kg
Mg: ≤5 mg/kg
Mn: ≤5 mg/kg
Na: ≤10 mg/kg
Ni: ≤5 mg/kg
Pb: ≤5 mg/kg
Zn: ≤5 mg/kg

Absorption

≥2000 at 337 nm (mol. absorption)

Chaîne SMILES 

OC(=O)\C(=C\c1ccc(O)cc1)C#N

InChI

1S/C10H7NO3/c11-6-8(10(13)14)5-7-1-3-9(12)4-2-7/h1-5,12H,(H,13,14)/b8-5+

Clé InChI

AFVLVVWMAFSXCK-VMPITWQZSA-N

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Catégories apparentées

Description générale

α-Cyano-4-hydroxycinnamic acid (α-CHCA) is widely used as a matrix in order to facilitate ionization of peptides and proteins in a matrix-assisted laser desorption/ionization (MALDI) time-of-flight (TOF) mass spectrometer.

Application

α-CHCA was used as matrix in improving the detection of low concentration protein digests on MALDI-TOF.

Autres remarques

Matrix substance used in MALDI-MS (matrix-assisted laser desorption ionization MS) peptide analysis in proteomics.

Produit(s) apparenté(s)

Réf. du produit
Description
Tarif

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αAcide α-cyano-4-hydroxycinnamique, suitable for MALDI-TOF MS

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MSCAL1

ProteoMass™ Peptide and Protein MALDI-MS Calibration Kit, Peptide and Protein MALDI MS Calibration Standard

MSCAL2

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MSCAL3

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2′,6′-Dihydroxyacetophenone, matrix substance for MALDI-MS, ≥99.5%

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2′,4′,6′-Trihydroxyacetophenone monohydrate, matrix substance for MALDI-MS, ≥99.5%

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MALDI validation set PS, PMMA, PDMS, PEG and PSS Mp ~4′300 - 6′500

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trans-2-[3-(4-tert-Butylphenyl)-2-methyl-2-propenylidene]malononitrile, matrix substance for MALDI-MS, ≥99.0% (HPLC)

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(N-Succinimidyloxycarbonylmethyl)tris(2,4,6-trimethoxyphenyl)phosphonium bromide, for protein sequence analysis (by MALDI-MS), ≥98.5%

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2,5-Dihydroxybenzoic acid, matrix substance for MALDI-MS, >99.0% (HPLC)

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α(2→3,6,8,9) Neuraminidase from Arthrobacter ureafaciens, Proteomics Grade, suitable for MALDI-TOF MS

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αAcide α-cyano-4-hydroxycinnamique, matrix substance for MALDI-MS, Ultra pure

39319

2,5-Dihydroxybenzoic acid, matrix substance for MALDI-MS, ≥99.5% (HPLC), Ultra pure

49508

Sinapic acid, matrix substance for MALDI-MS, ≥99.5%, Ultra pure

50862

Super-DHB, suitable for matrix substance for MALDI-MS, ≥99.0%

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2′,3′-Dideoxycytidine 5′-triphosphate sodium salt solution, suitable for MALDI-MS, ≥98.0% (HPLC)

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3′-Deoxythymidine 5′-triphosphate sodium salt solution, BioChemika, puriss. p.a., suitable for MALDI-MS, ≥98.0% (HPLC)

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ProteoMass™ Guanidination Kit, For improving MALDI-MS sensitivity and peptide sequence coverage

MSCAL4

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94141

4-Chloro-α-cyanocinnamic acid, matrix substance for MALDI-MS, ≥95.0% (HPLC)

89063

4-Bromo-α-cyanocinnamic acid, matrix substance for MALDI-MS, ≥95.0% (HPLC)

77081

α-Cyano-4-fluorocinnamic acid, matrix substance for MALDI-MS, ≥95.0% (HPLC)

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α-Cyano-2,3,4,5,6-pentafluorocinnamic acid, matrix substance for MALDI-MS, ≥95.0% (HPLC)

39379

4-Chloro-α-cyanocinnamic acid - α-Cyano-2,4-difluorocinnamic acid mixture, matrix substance for MALDI-MS, ≥95.0% (sum of both components, HPLC)

68914

4-Bromo-α-cyanocinnamic acid - 4-Chloro-α-cyanocinnamic acid mixture, matrix substance for MALDI-MS, ≥95.0% (sum of both components, HPLC)

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PFS31

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PFS32

SpheriCal™ Aqua, Peptide High, suitable for MALDI-MS

PFS20

SpheriCal™ Neat, Peptide Low, suitable for MALDI-MS

PFS21

SpheriCal™ Neat, Peptide Medium, suitable for MALDI-MS

PFS22

SpheriCal™ Neat, Peptide High, suitable for MALDI-MS

PFS23

SpheriCal™ Neat, Protein Low, suitable for MALDI-MS

PFS30

SpheriCal™ Aqua, Peptide Low, suitable for MALDI-MS

69028

4-Phenyl-α-cyanocinnamamide, matrix substance for MALDI-MS, ≥98.5% (HPLC)

900666

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Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H317

Classification des risques

Skin Sens. 1B

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

dust mask type N95 (US), Eyeshields, Gloves

Choose from one of the most recent versions:

Certificats d'analyse (COA)

Lot/Batch Number
BCCL3737
BCCH7026
BCCG3811
BCCC8081
BCBZ5249

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If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

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2′,4′,6′-Trihydroxyacetophenone monohydrate matrix substance for MALDI-MS, ≥99.5%

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Sinapic acid ≥98%, powder

Sigma-Aldrich

D7927

Sinapic acid

S.D. Patterson, V. Katta
Analytical Chemistry, 66, 3729-3729 (1994)
Bin Li et al.
Toxicological sciences : an official journal of the Society of Toxicology, 116(1), 23-31 (2010-04-17)
Studies in mice and guinea pigs have shown that albumin is a new biomarker of organophosphorus toxicant (OP) and nerve agent exposure. Our goal was to determine whether OP-labeled albumin could be detected in the blood of humans exposed to
J Gobom et al.
Analytical chemistry, 73(3), 434-438 (2001-02-24)
We present a new MALD1 sample preparation technique for peptide analysis using the matrix alpha-cyano-4-hydroxy-cinnamic acid (CHCA) and prestructured sample supports. The preparation integrates sample purification, based on the affinity of microcrystalline CHCA for peptides, thereby simplifying the analysis of
Xiangping Zhu et al.
Journal of biomolecular techniques : JBT, 14(4), 298-307 (2004-01-13)
Alpha-cyano-4-hydroxycinnamic acid (alpha-CHCA) as a matrix facilitates the ionization of proteins and peptides in a matrix-assisted laser desorption/ionization (MALDI) time-of-flight (TOF) mass spectrometer. The matrix itself also ionizes and so do its sodium and potassium adducts. Matrix clusters and metal
Kevser Biberoglu et al.
Biochimica et biophysica acta, 1834(4), 745-753 (2013-01-29)
Acetylcholinesterase (AChE) in the serum of fetal cow is a tetramer. The related enzyme, butyrylcholinesterase (BChE), in the sera of humans and horse requires polyproline peptides for assembly into tetramers. Our goal was to determine whether soluble tetrameric AChE includes
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