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SML4070

Sigma-Aldrich

Dihydromyricetin

new

≥98% (HPLC)

Synonym(e):

(+)-Ampelopsin, (+)-Dihydromyricetin, (2R,3R)-3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-2,3-dihydrochromen-4-one, Ampelopsin, DHM

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About This Item

Empirische Formel (Hill-System):
C15H12O8
CAS-Nummer:
27200-12-0
Molekulargewicht:
320.25
MDL-Nummer:
MFCD00189451
UNSPSC-Code:
41116107
UNSPSC-Code:
12352200

Qualitätsniveau

100

Assay

≥98% (HPLC)

Form

powder

Lagerbedingungen

protect from light

Farbe

white to beige

Löslichkeit

DMSO: 2 mg/mL, clear

Lagertemp.

-10 to -25°C

Biochem./physiol. Wirkung

Antioxidant, anti-cancer flavanonol with anti-alcohol intoxication effects, significantly impacts metabolic regulation and cancer chemoprevention through pathways like AMPK and SPHK1/mTOR.Dihydromyricetin (DHM) is a potent flavonoid known for its antioxidative, anti-inflammatory, anticancer, and antimicrobial properties, and plays a key role in modulating metabolism with minimal side effects. It operates by either scavenging or generating reactive oxygen species (ROS) to selectively target cancer cells, while sparing normal cells. DHM acts through multiple pathways including AMPK, affecting autophagy and glucose transport. Additionally, Dihydromyricetin inhibits ferroptosis via the SPHK1/mTOR pathway, modulates the Prx2 cascade through Nrf2, and contributes to cancer prevention and diabetes treatment by altering redox balance, gene expression, and improving metabolism, also involving AMPK, PI3K/Akt, PPAR pathways, and microRNAs.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

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Jie Fang et al.
Clinical and experimental pharmacology & physiology, 51(3), e13833-e13833 (2024-02-02)
Previous clinical reports have shown that capecitabine, an oral prodrug of 5-fluorouracil (5-Fu), can induce peripheral neuropathy, resulting in numbness, paresthesia and hypoesthesia. However, the mechanism through which capecitabine causes peripheral nerve injury remains unclear. Here, we demonstrate that systemic
Yi Shen et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 32(1), 390-401 (2012-01-06)
Alcohol use disorders (AUDs) constitute the most common form of substance abuse. The development of AUDs involves repeated alcohol use leading to tolerance, alcohol withdrawal syndrome, and physical and psychological dependence, with loss of ability to control excessive drinking. Currently
Zhenzhu Sun et al.
Biochemical pharmacology, 175, 113888-113888 (2020-03-01)
Doxorubicin (DOX) is a powerful anthracycline antineoplastic drug whose clinical application is limited by serious cardiotoxic side effects. Dihydromyricetin (DHM), a flavonoid compound extracted from the Japanese raisin tree (Hovenia dulcis), is cardioprotective in patients with heart failure; however, the

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