SML3814

Firibastat

≥98% (HPLC)

• Synonym(e): QGC-001, (3S)-3-Amino-4-[[(2S)-2-amino-4-sulfobutyl]disulfanyl]butane-1-sulfonic acid, (3S,3′S)-4,4′-Dithiobis(3-aminobutane-1-sulfonic acid, QGC 001, QGC001, RB 150, RB-150, RB150
• Empirische Formel (Hill-System): C₈H₂₀N₂O₆S₄
• CAS-Nummer: 648927-86-0
• Molekulargewicht: 368.51
• MDL-Nummer: MFCD20921962
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to beige
• Löslichkeit: H₂O: 2 mg/mL, clear (Warmed)
• Lagertemp.: -10 to -25°C

Beschreibung

Biochem./physiol. Wirkung

Firibastat (RB150; QGC001) is an orally active, blood-brain barrier-permeant prodrug composed of two molecules of disulfide-linked aminopeptidase A (APA; glutamyl aminopeptidase) active-site inhibitor EC33 (Ki = 300 nM) that are released via the action of brain reductase in the brain. Firibastat exhibits antihypertensive efficacy in vivo (Blood pressure reduction ED50 = 30 mg/kg via p.o. in spontaneously hypertensive rats).

Orally active, brain-permeant precursor of the aminopeptidase A (APA; glutamyl aminopeptidase) active-site inhibitor EC33 with antihypertensive efficacy in vivo.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable