SML3042

iP300

≥97% (HPLC)

• Synonym(e): 2-(3′-Fluoro-5′-(1-(2-(methylamino)-2-oxoethyl)-1H-pyrazol-4-yl)-2,5-dioxo-2′,3′-dihydrospiro[imidazolidine-4,1′-indene]-1-yl)-N-(4-fluorobenzyl)-N-(1,1,1-trifluoropropan-2-yl)acetamide, 3-Fluoro-N-[(4-fluorophenyl)methyl]-2,3-dihydro-5-[1-[2-(methylamino)-2-oxoethyl]-1H-pyrazol-4-yl]-2,5-dioxo-N-(2,2,2-trifluoro-1-methylethyl)spiro[imidazolidine-4,1-[1H]indene]-1-acetamide, N-(4-fluorobenzyl)-2-(3-fluoro-5-{1-[2-(methylamino)-2-oxoethyl]-1H-pyrazol-4-yl}-2,5-dioxo-2,3-dihydro-1H-spiro[imidazolidine-4,1-inden]-1-yl)-N-(1,1,1-trifluoropropan-2-yl)acetamide, iP300v/w, iP300w and iP300v mix, iP300w/v
• Empirische Formel (Hill-System): C₂₉H₂₇F₅N₆O₄
• CAS-Nummer: 2624336-90-7
• Molekulargewicht: 618.55
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥97% (HPLC)
• Form: powder

Eigenschaften

• Quality Segment: 100
• assay: ≥97% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: −20°C
• SMILES string: O=C(NC1(C2=O)CC(C3=C1C=CC(C4=CN(N=C4)CC(NC)=O)=C3)F)N2CC(N(CC5=CC=C(C=C5)F)C(C(F)(F)F)C)=O
• InChI: 1S/C29H27F5N6O4/c1-16(29(32,33)34)39(12-17-3-6-20(30)7-4-17)25(42)15-40-26(43)28(37-27(40)44)10-23(31)21-9-18(5-8-22(21)28)19-11-36-38(13-19)14-24(41)35-2/h3-9,11,13,16,23H,10,12,14-15H2,1-2H3,(H,35,41)(H,37,44)
• InChI key: SWXCHCQCWFXILM-UHFFFAOYSA-N

Beschreibung

Biochem/physiol Actions

Potent histone acetyltransferase p300/CBP inhibitor that prevents DUX4-induced cytotoxicity and transcription activity in vitro and in vivo.

iP300, a mixture of 8 diastereomers, is a potent histone acetyltransferase (HAT) p300/CBP inhibitor (p300 IC50 = 33 nM by H3K9Ac HTRF assay). An active diastereomer(s)-enriched pool (iP300w) obtained by partial HPLC separation prevents DUX4-induced cytotoxicity and transcription activity in human myoblast LHCN-M2 cultures (0.1-1 μM) and shows in vivo efficacy against muscle loss (0.3 mg/kg/day i.p.) in a murine model of facioscapulohumeral muscular dystrophy (FSHD).

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable