SML0245

Candesartancilexetil

≥98% (HPLC)

• Synonym(e): 2-Ethoxy-1-[[2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl]methyl]-1H-benzimidazol-7-carbonsäure-1-[[(cyclohexyloxy)carbonyl]oxy]ethylester, TCV 116, TCY 116
• Empirische Formel (Hill-System): C₃₃H₃₄N₆O₆
• CAS-Nummer: 145040-37-5
• Molekulargewicht: 610.66
• NACRES: NA.77
• PubChem Substance ID: 329825255
• UNSPSC Code: 12352200
• MDL number: MFCD00871371
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: ≥15 mg/mL
• originator: Takeda
• storage temp.: 2-8°C
• SMILES string: CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc4ccc(cc4)-c5ccccc5-c6nnn[nH]6
• InChI: 1S/C33H34N6O6/c1-3-42-32-34-28-15-9-14-27(31(40)43-21(2)44-33(41)45-24-10-5-4-6-11-24)29(28)39(32)20-22-16-18-23(19-17-22)25-12-7-8-13-26(25)30-35-37-38-36-30/h7-9,12-19,21,24H,3-6,10-11,20H2,1-2H3,(H,35,36,37,38)
• InChI key: GHOSNRCGJFBJIB-UHFFFAOYSA-N
• Gene Information: human ... AGTR1(185)

Beschreibung

Biochem/physiol Actions

Candesartancilexetil ist die Prodrug-Form des potenten Angiotensin II-Rezeptorantagonisten Candesartan. Das Prodrug wird durch Esterasen im Darm gespaltet, um das aktive Molekül freizusetzen.

Candesartancilexetil ist ein Nicht-Peptid-Angiotensin(AT2)-Rezeptorantagonist.

Features and Benefits

This compound is featured on the Angiotensin Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Takeda. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Sicherheitshinweise

• pictograms: GHS08
• signalword: Danger
• hcodes: H360D,H373
• pcodes: P202 - P260 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Repr. 1B - STOT RE 2 Oral
• target_organs: Kidney,Blood
• Lagerklasse: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3
• flash_point_f: No data available
• flash_point_c: No data available