P8390

Picrotoxinin

• Empirische Formel (Hill-System): C₁₅H₁₆O₆
• CAS-Nummer: 17617-45-7
• Molekulargewicht: 292.28
• MDL-Nummer: MFCD00078765
• UNSPSC-Code: 41116107
• PubChem Substanz-ID: 24898746
• NACRES: NA.77

Eigenschaften

• Form: powder
• SMILES String: [H][C@@]12OC(=O)[C@]([H])([C@@H]1C(C)=C)[C@]3(O)C[C@H]4O[C@]45C(=O)O[C@@]2([H])[C@]35C
• InChI: 1S/C15H16O6/c1-5(2)7-8-11(16)19-9(7)10-13(3)14(8,18)4-6-15(13,21-6)12(17)20-10/h6-10,18H,1,4H2,2-3H3/t6-,7+,8+,9-,10-,13-,14-,15+/m1/s1
• InChIKey: PIMZUZSSNYHVCU-KBLUICEQSA-N

Beschreibung

Allgemeine Beschreibung

Picrotoxinin is a component of picrotoxin[1] and can be derived from plants. It is a non-nitrogenous compound.[2]

Anwendung

Picrotoxinin has been used as an agonist of taste 2 receptor member 14 (TAS2R14) to perform an array-based bitter receptor screening assay[3] and to study the effect of calcium buffering and calcium sensor type on its sensitivity.[4]

Biochem./physiol. Wirkung

GABA_A receptor antagonist; binds to the GABA receptor-linked Cl⁻ channel.

Picrotoxinin acts as a potent convulsant.[1]

Leistungsmerkmale und Vorteile

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This compound is featured on the Glycine Receptor page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Sonstige Hinweise

Active component of picrotoxin

Sicherheitshinweise

• Piktogramme: GHS06
• Signalwort: Danger
• H-Sätze: H300
• P-Sätze: P301 + P310 + P330
• Gefahreneinstufungen: Acute Tox. 2 Oral
• Lagerklassenschlüssel: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges