P7412

Pirenzepine dihydrochloride

≥98% (TLC), powder

• Synonym(e): 5,11-Dihydro-11-[(4-methyl-1-piperazinyl)acetyl]-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one dihydrochloride
• Empirische Formel (Hill-System): C₁₉H₂₁N₅O₂ · 2HCl
• CAS-Nummer: 29868-97-1
• Molekulargewicht: 424.32
• EG-Nummer: 249-907-5
• MDL-Nummer: MFCD00055214
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24277863
• NACRES: NA.77

Eigenschaften

• Assay: ≥98% (TLC)
• Form: powder
• Farbe: white to light yellow
• Löslichkeit: H₂O: 50 mg/mL
• SMILES String: Cl[H].Cl[H].CN1CCN(CC1)CC(=O)N2c3ccccc3C(=O)Nc4cccnc24
• InChI: 1S/C19H21N5O2.2ClH/c1-22-9-11-23(12-10-22)13-17(25)24-16-7-3-2-5-14(16)19(26)21-15-6-4-8-20-18(15)24;;/h2-8H,9-13H2,1H3,(H,21,26);2*1H
• InChIKey: FFNMBRCFFADNAO-UHFFFAOYSA-N
• Angaben zum Gen: human ... CHRM1(1128)

Beschreibung

Allgemeine Beschreibung

Pirenzepine dihydrochloride is an anticholinergic agent.[1][2] It is also considered as an antiulcer drug.[3] It is used to treat myopia, gastric and duodenal ulcers.[1][4] Pirenzepine dihydrochloride induces the dimerization of muscarinic M1 receptors.[5]

Anwendung

Pirenzepine dihydrochloride has been used

• in transactivation of fibroblast growth factor receptor (FGFR).[6]
• as a supplement in cell culture.[7]
• for the stimulation of human fibroblasts[8]

Biochem./physiol. Wirkung

Selective M₁ muscarinic acetylcholine receptor antagonist.

Leistungsmerkmale und Vorteile

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Acetylcholine Receptors (Muscarinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Vorsicht

Hygroscopic; store desiccated at room temperature.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 2
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)