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N3529

Sigma-Aldrich

NAN-190 hydrobromide

Synonym(e):

1-(2-Methoxyphenyl)-4-[4-(2-phthalimido)butyl]piperazine hydrobromide

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About This Item

Empirische Formel (Hill-System):
C23H27N3O3 · HBr
CAS-Nummer:
115338-32-4
Molekulargewicht:
474.39
MDL-Nummer:
MFCD00078590
UNSPSC-Code:
12352200
PubChem Substanz-ID:
24278108

SMILES String

Br.COc1ccccc1N2CCN(CCCCN3C(=O)c4ccccc4C3=O)CC2

InChI

1S/C23H27N3O3.BrH/c1-29-21-11-5-4-10-20(21)25-16-14-24(15-17-25)12-6-7-13-26-22(27)18-8-2-3-9-19(18)23(26)28;/h2-5,8-11H,6-7,12-17H2,1H3;1H

InChIKey

AXRUEPFPTQYHQD-UHFFFAOYSA-N

Angaben zum Gen

human ... HTR1A(3350)

Biochem./physiol. Wirkung

Potent 5-HT1A serotonin receptor antagonist active in the nM range.

Piktogramme

Exclamation markEnvironment
GHS07,GHS09

Signalwort

Warning

Gefahreneinstufungen

Aquatic Acute 1 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Lagerklassenschlüssel

13 - Non Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Gloves

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Jarod Swant et al.
PloS one, 5(6), e11382-e11382 (2010-07-09)
Methamphetamine (METH) is an addictive psychostimulant whose societal impact is on the rise. Emerging evidence suggests that psychostimulants alter synaptic plasticity in the brain--which may partly account for their adverse effects. While it is known that METH increases the extracellular
Pei-Lu Yi et al.
Journal of biomedical science, 14(6), 829-840 (2007-07-28)
Sedative-hypnotic medications, including benzodiazepines and non-benzodiazepines, are usually prescribed for the insomniac patients; however, the addiction, dependence and adverse effects of those medications have drawn much attention. In contrast, suanzaorentang, a traditional Chinese herb remedy, has been efficiently used for
Nantaka Khorana et al.
Pharmacology, biochemistry, and behavior, 91(3), 385-392 (2008-09-10)
Co-administration of the 5-HT1A serotonin receptor agonist (+/-)8-hydroxy-2-(N,N-di-n-propylamino)tetralin [(+/-)8-OH DPAT] enhances the discriminative stimulus effects of the classical hallucinogen 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane (DOM) in rats. In the present investigation, using Sprague-Dawley rats trained to discriminate DOM (1.0 mg/kg) from saline vehicle under
R Sterniczuk et al.
Neuroscience, 153(3), 571-580 (2008-04-15)
Chronic desynchronization between the mammalian circadian pacemaker and its external environment, such as that observed from shift work or jet lag, can lead to various long-term health consequences. The circadian clock can be reset by exposure to light, although the
Jordan D Chambers et al.
PloS one, 6(5), e19597-e19597 (2011-05-17)
After a meal, the gastrointestinal tract exhibits a set of behaviours known as the fed state. A major feature of the fed state is a little understood motor pattern known as segmentation, which is essential for digestion and nutrient absorption.
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