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L137

Sigma-Aldrich

L-733,060 hydrochloride

solid, ≥98% (HPLC)

Synonym(e):

(2S,3S)-3-[(3,5-bis(Trifluoromethyl)phenyl)methoxy]-2-phenylpiperidine hydrochloride

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About This Item

Empirische Formel (Hill-System):
C20H19F6NO · HCl
CAS-Nummer:
148687-76-7
Molekulargewicht:
439.82
MDL-Nummer:
MFCD06798982
UNSPSC-Code:
12352202
PubChem Substanz-ID:
24278530

Assay

≥98% (HPLC)

Form

solid

Farbe

white

Löslichkeit

DMSO: >10 mg/mL
H2O: insoluble

Lagertemp.

2-8°C

SMILES String

Cl[H].FC(F)(F)c1cc(CO[C@@H]2CCCN[C@@H]2c3ccccc3)cc(c1)C(F)(F)F

Angaben zum Gen

human ... TACR1(6869)

Biochem./physiol. Wirkung

Non-peptide NK1 tachykinin receptor antagonist; selective for guinea pig/human versus rat/mouse. Micromolar concentrations of L-733,060 inhibit the growth of human gastric and colon adenocarcinomas.in a dose-dependent manner, eventually leading to apoptosis in both cell lines.

Rechtliche Hinweise

Manufactured and sold under license from Merck & Co., Inc., Kenilworth, NJ, U.S.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

Analysenzertifikate (COA)

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Jitka Myskova et al.
Journal of medical entomology, 45(1), 133-138 (2008-02-21)
Quantification of Leishmania parasites in the sand fly digestive tract is important for evaluation of vector competence. We compared quantitative polymerase chain reaction (Q-PCR) with two "traditional" methods, estimation in situ and direct counting with the aid of a hemocytometer
P Kiatpapan et al.
Journal of bioscience and bioengineering, 92(5), 459-465 (2005-10-20)
To develop systems for the expression of heterologous genes in probiotic strains of Lactobacillus and Propionibacterium, we used Lactobacillus plantarum and Propionibacterium freudenreichii and a modified gene encoding cholesterol oxidase (choA) from Streptomyces sp. to generate working models. The acetyl
Y Kaneko et al.
Journal of bioscience and bioengineering, 89(1), 62-67 (2005-10-20)
Lactobacillus plantarum NC13, a strain derived from the L. plantarum strain L137 isolated from a traditional fermented food produced in the Philippines, contains 9 of the 15 plasmids in the parental strain. To construct a shuttle vector between L. plantarum
Jong-Hyun Kim et al.
Journal of bioscience and bioengineering, 107(2), 124-129 (2009-02-17)
A gene (apuA) encoding amylopullulanase from a starch-hydrolyzing lactic acid bacterium, Lactobacillus plantarum L137, which had been isolated from traditional fermented food made from fish and rice in the Philippines, was found to contain two unique amino acid repeating units
Marisa Rosso et al.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 29(4), 245-254 (2008-09-11)
It has been demonstrated that substance P (SP) and neurokinin-1 (NK-1) receptor antagonist L-733,060 induces cell proliferation and inhibition, respectively, in several human cancer cell lines. At present, it is unknown whether such actions are exerted on human gastric and
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