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G5918

Sigma-Aldrich

GR 113808

≥98% (HPLC), solid

Synonym(e):

1-[2-[(Methylsulfonyl)-amino]ethyl]-4-piperidinyl]methyl 1-methyl-1H-indole-3-carboxylate

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About This Item

Empirische Formel (Hill-System):
C19H27N3O4S
CAS-Nummer:
144625-51-4
Molekulargewicht:
393.50
MDL-Nummer:
MFCD00912901
UNSPSC-Code:
12352200
PubChem Substanz-ID:
24278311
NACRES:
NA.77

Assay

≥98% (HPLC)

Form

solid

Farbe

white to light pink

Löslichkeit

DMSO: >20 mg/mL

Ersteller

GlaxoSmithKline

Lagertemp.

2-8°C

SMILES String

Cn1cc(C(=O)OCC2CCN(CCNS(C)(=O)=O)CC2)c3ccccc13

InChI

1S/C19H27N3O4S/c1-21-13-17(16-5-3-4-6-18(16)21)19(23)26-14-15-7-10-22(11-8-15)12-9-20-27(2,24)25/h3-6,13,15,20H,7-12,14H2,1-2H3

InChIKey

MOZPSIXKYJUTKI-UHFFFAOYSA-N

Angaben zum Gen

human ... HTR4(3360)
rat ... Htr3a(79246) , Htr4(25324)

Anwendung

GR 113808 has been used as a serotonin receptor 4 (5-HT4R) blocker to study its effects on the calcium (Ca2+) transients in rat ventricular cardiomyocytes. It has also been used as a 5-HT4R antagonist to study its effects on de novo enteric neurogenesis in post-embryonic zebrafish.

Biochem./physiol. Wirkung

GR 113808 is a 5-HT4 serotonin receptor antagonist.

Leistungsmerkmale und Vorteile

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Rechtliche Hinweise

Sold for research purposes under agreement from Glaxo­Smith­Kline

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

Analysenzertifikate (COA)

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Sigma-Aldrich

Sigma-Aldrich

H6648

Hanks-Salze -Lösung

Polyethylenglykol 400, for synthesis

Sigma-Aldrich

8.07485

Polyethylenglykol

Dispase® II (neutrale Protease, Klasse II) lyophilized, from bacterial, Roche, pkg of 5 × 1 g

Roche

04942078001

Dispase® II (neutrale Protease, Klasse II)

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