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H4644

Sigma-Aldrich

Hypercalcemia of malignancy factor 1-40 human

≥95% (HPLC), suitable fo drug transporter assays

Synonym(e):

Ala-Val-Ser-Glu-His-Gln-Leu-Leu-His-Asp-Lys-Gly-Lys-Ser-Ile-Gln-Asp-Leu-Arg-Arg-Arg-Phe-Phe-Leu-His-His-Leu-Ile-Ala-Glu-Ile-His-Thr-Ala-Glu-Ile-Arg-Ala-Thr-Ser, PTH-Like Adenylate Cyclase Stimulating Protein, PTHrP (1-40), Parathyroid hormone-related protein (1-40)

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About This Item

Empirische Formel (Hill-System):
C207H334N66O58
CAS-Nummer:
120298-73-9
Molekulargewicht:
4675.27
MDL-Nummer:
MFCD00081712
UNSPSC-Code:
12352201
NACRES:
NA.26

product name

Hypercalcemia of malignancy factor 1-40 human, ≥95% (HPLC)

Qualitätsniveau

200

Assay

≥95% (HPLC)

Form

solid

Methode(n)

drug transporter assay: suitable

UniProt-Hinterlegungsnummer

P12272

Lagertemp.

−20°C

Angaben zum Gen

human ... PTHLH(5744)

Amino Acid Sequence

Ala-Val-Ser-Glu-His-Gln-Leu-Leu-His-Asp-Lys-Gly-Lys-Ser-Ile-Gln-Asp-Leu-Arg-Arg-Arg-Phe-Phe-Leu-His-His-Leu-Ile-Ala-Glu-Ile-His-Thr-Ala-Glu-Ile-Arg-Ala-Thr-Ser

Biochem./physiol. Wirkung

Hypercalcemia of malignancy factor fragment 1-40 human is a parathyroid hormone-like protein (PLP) fragment used to study parathyroid hormone-related signaling pathways.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

Analysenzertifikate (COA)

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Parathyroid hormone-related peptide and primary hyperparathyroidism.
Testini M, Gurrado A, et al.
Frontiers in Bioscience, 2, 299-312 (2010)
C Cataisson et al.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 15(11), 2129-2139 (2000-11-25)
Parathyroid hormone-related protein (PTHrP) is the main mediator of humoral hypercalcemia of malignancy (HHM) and it is produced by many tumors, including breast cancers. Breast epithelial cells as well as breast cancer tumors and cell lines have been reported as
T J Rosol et al.
Domestic animal endocrinology, 8(4), 499-507 (1991-10-01)
The effects of transforming growth factor-alpha (TGF alpha) were determined on the ability of parathyroid hormone (PTH) or parathyroid hormone-related protein (PTHrP) to stimulate bone resorption and adenylate cyclase in vitro. Bovine PTH-(1-34) and human PTHrP-(1-34) were equipotent in their
Koh Sato et al.
Seminars in oncology, 30(5 Suppl 16), 167-173 (2003-11-13)
Parathyroid hormone-related protein (PTHrP) plays a central role in humoral hypercalcemia of malignancy (HHM), which is one of the most frequent paraneoplastic syndromes. PTHrP produced by the tumor acts through a common PTH/PTHrP receptor to promote bone resorption, inhibit calcium
J M Moseley et al.
Proceedings of the National Academy of Sciences of the United States of America, 84(14), 5048-5052 (1987-07-01)
A protein with biological activities similar to parathyroid hormone (PTH) has been purified from serum-free culture medium obtained from a human lung cancer cell line (BEN). A major protein band of 18 kDa was obtained on NaDodSO4/polyacrylamide gels, with faint
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