G9659

GBR 12935 dihydrochloride

≥98% (TLC), powder

• Synonym(e): 1-[2-(Diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazine dihydrochloride
• Empirische Formel (Hill-System): C₂₈H₃₄N₂O · 2HCl
• CAS-Nummer: 67469-81-2
• Molekulargewicht: 487.50
• MDL-Nummer: MFCD00083175
• UNSPSC-Code: 12352202
• PubChem Substanz-ID: 24277959
• NACRES: NA.77

Eigenschaften

• Assay: ≥98% (TLC)
• Form: powder
• Farbe: white
• Löslichkeit: H₂O: 20 mg/mL (with warming)
• SMILES String: Cl[H].Cl[H].C(CN1CCN(CCOC(c2ccccc2)c3ccccc3)CC1)Cc4ccccc4
• InChI: 1S/C28H34N2O.2ClH/c1-4-11-25(12-5-1)13-10-18-29-19-21-30(22-20-29)23-24-31-28(26-14-6-2-7-15-26)27-16-8-3-9-17-27;;/h1-9,11-12,14-17,28H,10,13,18-24H2;2*1H
• InChIKey: NQWRSILGEXNJIT-UHFFFAOYSA-N

Beschreibung

Anwendung

GBR 12935 dihydrochloride has been used as a dopamine reuptake inhibitor to study its effects on noradrenergic stimulation in the medial prefrontal cortex of rats (mPFC).[1] It has also been used as a selective dopamine transporter (DAT) inhibitor to study its effects on behavior and neurochemical response in enriched condition (EC) and impoverished condition (IC) rats.[2]

Biochem./physiol. Wirkung

GBR 12935 inhibits the dopamine[2] and norepinephrine transporters with K_is of 21.5 nM and 225 nM, respectively. It does not inhibit the serotonin transporter (K_i = 6.5 mM). GBR 12935 binds to a nondopaminergic piperazine site in blood platelets and brain that has been identified as cytochrome P450.

Leistungsmerkmale und Vorteile

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Sicherheitshinweise

• Lagerklassenschlüssel: 13 - Non Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)