The absorbance of the solution at 280 nm is read and the protein concentration calculated using an E(1%) of 17.
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C1617
C Reactive Protein human
recombinant, expressed in E. coli, liquid
Synonym(e):
CRP
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| Ihnen/SKU | Verfügbarkeit | Preis |
|---|---|---|
1 mg | Warenkorb auf Verfügbarkeit prüfen | € 761,00 |
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Unterstützung erhaltenGeneral description
C-reactive protein (CRP), a homopentameric acute-phase inflammatory protein, is produced mainly in liver hepatocytes. This highly conserved plasma protein is also produced by smooth muscle cells, macrophages, endothelial cells, lymphocytes, and adipocytes. It belongs to the pentraxin family.[1]
Application
C Reactive Protein human has been used:
- as a component in differentiation medium to study the effects of C-reactive protein (CRP) on the size of myotubes and myotube mixed protein synthesis (MPS)[2]
- to study the influence of serum CRP level from elderly on endothelial cell proliferation in human umbilical vein endothelial cells (HUVEC)[3]
- to study the roles and connections of nicotine, monocytic interleukin 6 (IL-6), α7 nicotinic acetylcholine receptor (α7-nAChR), and CRP in the development of coronary artery spasm (CAS)[4]
Biochem/physiol Actions
C-reactive protein (CRP) is a protein that could precipitate the C-polysaccharide of pneumococcal cell walls. CRP is widely used as a clinical marker of the state of inflammation, since its production by hepatocytes increases during the acute phase of the inflammatory response.
C-reactive protein (CRP) plays a key role in the complement pathway, apoptosis, phagocytosis, nitric oxide (NO) release, and the production of interleukin-6 and tumor necrosis factor-α. It participates in the uptake of low-density lipoprotein in macrophages. CRP levels are elevated in people suffering from appendicitis, cholecystitis, pancreatitis, and meningitis. It plays a vital role in the pathophysiology of cardiovascular disease. Hence it is used as a marker of infection and cardiovascular events.[1]
Analysis Note
A highly purified protein and made by a fermentation process using genetically modified E. coli.
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Dieser Artikel | |||
|---|---|---|---|
| recombinant expressed in E. coli | recombinant - | recombinant - | recombinant - |
| Quality Level 200 | Quality Level 200 | Quality Level 200 | Quality Level 200 |
| form liquid | form buffered aqueous solution | form - | form lyophilized powder |
| mol wt 23 kDa | mol wt - | mol wt antigen 24 kDa | mol wt - |
| Gene Information human ... CRP(1401) | Gene Information human ... CRP(1401) | Gene Information human ... CRP(1401) | Gene Information human ... CRP(1401) |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. −20°C | storage temp. 2-8°C |
Lagerklasse
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
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How is the protein concentration of product C1617, human recombinant C-Reactive Protein, determined?
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What is the Department of Transportation shipping information for this product?
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Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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