PHR1143

Lisinopril

Pharmaceutical Secondary Standard; Certified Reference Material

• Synonym(e): 1-[N²-((S)-1-Carboxy-3-phenylpropyl)-L-lysyl]-L-prolin Dihydrat, MK-521
• Empirische Formel (Hill-System): C₂₁H₃₁O₅N₃ · 2H₂O
• CAS-Nummer: 83915-83-7
• Molekulargewicht: 441.52
• MDL-Nummer: MFCD01698825
• UNSPSC-Code: 41116107
• PubChem Substanz-ID: 329823163
• NACRES: NA.24

Eigenschaften

• Qualität: certified reference material; pharmaceutical secondary standard
• Qualitätsniveau: 300
• Agentur: traceable to BP 695; traceable to Ph. Eur. L0702000; traceable to USP 1368609
• API-Familie: lisinopril
• Analysenzertifikat (CofA): current certificate can be downloaded
• Methode(n): HPLC: suitable; gas chromatography (GC): suitable
• Anwendung(en): pharmaceutical (small molecule)
• Format: neat
• Lagertemp.: 2-30°C
• SMILES String: [H]O[H].[H]O[H].NCCCC[C@H](N[C@@H](CCc1ccccc1)C(O)=O)C(=O)N2CCC[C@H]2C(O)=O
• InChI: 1S/C21H31N3O5.2H2O/c22-13-5-4-9-16(19(25)24-14-6-10-18(24)21(28)29)23-17(20(26)27)12-11-15-7-2-1-3-8-15;;/h1-3,7-8,16-18,23H,4-6,9-14,22H2,(H,26,27)(H,28,29);2*1H2/t16-,17-,18-;;/m0../s1
• InChIKey: CZRQXSDBMCMPNJ-ZUIPZQNBSA-N
• Angaben zum Gen: human ... ACE(1636)

Beschreibung

Allgemeine Beschreibung

Lisinopril is a lysine derivative of enalaprilat and belongs to the group of angiotensin converting enzyme (ACE) inhibitors. It is widely used as an orally active medication in the treatment of high blood pressure and may be used to treat congestive heart failure.

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Anwendung

Lisinopril may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using kinetic spectrophotometric technique.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem./physiol. Wirkung

Hemmstoff des Angiotensin-konvertierenden Enzyms (Angiotensin converting enzyme (ACE))

Hinweis zur Analyse

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Sonstige Hinweise

Die Werte der Analyten sind Lot-spezifisch.

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Fußnote

To see an example of a Certificate of Analysis for this material enter LRAB3302 in the slot below. This is an example certificate only and may not be the lot that you receive.

Sicherheitshinweise

• Piktogramme: GHS08
• Signalwort: Danger
• H-Sätze: H360D,H373
• P-Sätze: P202 - P260 - P280 - P308 + P313 - P405 - P501
• Gefahreneinstufungen: Repr. 1A - STOT RE 2
• Zielorgane: Kidney
• Lagerklassenschlüssel: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable