L6292

Lisinopril

≥98% (HPLC), Angiotensin converting enzyme (ACE) inhibitor., solid

• Synonym(e): 1-[N²-((S)-1-Carboxy-3-phenylpropyl)-L-lysyl]-L-prolin Dihydrat, MK-521
• Empirische Formel (Hill-System): C₂₁H₃₁O₅N₃ · 2H₂O
• CAS-Nummer: 83915-83-7
• Molekulargewicht: 441.52
• UNSPSC Code: 12352200
• PubChem Substance ID: 329817636
• NACRES: NA.32
• MDL number: MFCD01698825
• Assay: ≥98% (HPLC)
• Form: solid

Eigenschaften

• Produktname: Lisinopril, ≥98% (HPLC)
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: solid
• color: white
• solubility: H₂O: ≥10 mg/mL, DMSO: ~6.5 mg/mL (with heating and sonicating)
• storage temp.: 2-8°C
• SMILES string: [H]O[H].[H]O[H].NCCCC[C@H](N[C@@H](CCc1ccccc1)C(O)=O)C(=O)N2CCC[C@H]2C(O)=O
• InChI: 1S/C21H31N3O5.2H2O/c22-13-5-4-9-16(19(25)24-14-6-10-18(24)21(28)29)23-17(20(26)27)12-11-15-7-2-1-3-8-15;;/h1-3,7-8,16-18,23H,4-6,9-14,22H2,(H,26,27)(H,28,29);2*1H2/t16-,17-,18-;;/m0../s1
• InChI key: CZRQXSDBMCMPNJ-ZUIPZQNBSA-N
• Gene Information: human ... ACE(1636)

Beschreibung

Application

Lisinopril has been used to study the antifibrotic effect in duchenne muscular dystrophy mice. It has been used to study the changes in renal-structure and -function in TGR(mRen2)27 (transgenic rat harboring the murine Ren-2 gene) rats upon long term darbepoetin α treatment.

Biochem/physiol Actions

Hemmstoff des Angiotensin-konvertierenden Enzyms (Angiotensin converting enzyme (ACE))

Features and Benefits

This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Sicherheitshinweise

• Piktogramme: GHS08
• Signalwort: Danger
• Gefahrencodes: H360D,H373
• Sicherheitshinweise: P202 - P260 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Repr. 1A - STOT RE 2
• Zielorgane: Kidney
• Lagerklasse: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Was ist los?: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• PSA (Persönliche Schutzausrüstung): Eyeshields, Gloves, type N95 (US)