02580

O-[(Ethoxycarbonyl)-cyanmethylenamino]-N,N,N′,N′-tetramethyluronium-tetrafluoroborat

≥98.0% (CHN)

• Synonym(e): TOTU
• Lineare Formel: C₂H₅O₂CC(CN)=NOC[N(CH₃)₂]=N(CH₃)₂BF₄
• CAS-Nummer: 136849-72-4
• Molekulargewicht: 328.07
• MDL-Nummer: MFCD00192127
• UNSPSC-Code: 12352108
• PubChem Substanz-ID: 329747465
• NACRES: NA.22

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98.0% (CHN)
• Eignung der Reaktion: reaction type: Coupling Reactions
• mp (Schmelzpunkt): 144-145 °C; 145 °C (dec.) (lit.)
• Anwendung(en): peptide synthesis
• Lagertemp.: 2-8°C
• SMILES String: F[B-](F)(F)F.CCOC(=O)\C(=N/O\C(N(C)C)=[N+](/C)C)C#N
• InChI: 1S/C10H17N4O3.BF4/c1-6-16-9(15)8(7-11)12-17-10(13(2)3)14(4)5;2-1(3,4)5/h6H2,1-5H3;/q+1;-1/b12-8-;
• InChIKey: FPQVGDGSRVMNMR-JCTPKUEWSA-N

Beschreibung

Anwendung

Reactant for:
Watson-Crick pairing of oligonucleotides
Esterification of nucleosides to solid phase supports
Reagent for:
Synthesis of selective integrin avβ3 antagonists
Design and synthesis of double stranded DNA libraries
Preparation of conformationally contrained β-amino acid derivatives
Synthesis and application of methyleneoxy pseudopeptide building blocks

Sonstige Hinweise

Uronium-based coupling reagent for peptide synthesis suitable for critical cases

Sicherheitshinweise

• Piktogramme: GHS05,GHS07
• Signalwort: Danger
• H-Sätze: H302,H317,H318,H335
• P-Sätze: P261 - P264 - P280 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Gefahreneinstufungen: Acute Tox. 4 Oral - Eye Dam. 1 - Skin Sens. 1A - STOT SE 3
• Zielorgane: Respiratory system
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Gloves