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Sigma-Aldrich

Penicillin G Natriumsalz

96.0-102.0%

Synonym(e):

Benzylpenicillin Natriumsalz

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About This Item

Empirische Formel (Hill-System):
C16H17N2NaO4S
CAS-Nummer:
69-57-8
Molekulargewicht:
356.37
Beilstein:
3834217
EG-Nummer:
200-710-2
MDL-Nummer:
MFCD00069666
UNSPSC-Code:
51283424
eCl@ss:
34010400
PubChem Substanz-ID:
329750324
NACRES:
NA.85

Assay

96.0-102.0%

Form

powder

Wirkungsspektrum von Antibiotika

Gram-negative bacteria
Gram-positive bacteria

Wirkungsweise

cell wall synthesis | interferes

Lagertemp.

2-8°C

SMILES String

[Na+].[H][C@]12SC(C)(C)[C@@H](N1C(=O)[C@H]2NC(=O)Cc3ccccc3)C([O-])=O

InChI

1S/C16H18N2O4S.Na/c1-16(2)12(15(21)22)18-13(20)11(14(18)23-16)17-10(19)8-9-6-4-3-5-7-9;/h3-7,11-12,14H,8H2,1-2H3,(H,17,19)(H,21,22);/q;+1/p-1/t11-,12+,14-;/m1./s1

InChIKey

FCPVYOBCFFNJFS-LQDWTQKMSA-M

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Allgemeine Beschreibung

Chemical structure: ß-lactam
Penicillin G is a narrow spectrum natural antibiotic. It is effective against Streptococcus pneumoniae, groups A, B, C and G streptococci, nonenterococcal group D streptococci, viridans group streptococci, and non-penicillinase producing staphylococcus.

Anwendung

Penicillin G has been used to study penicillin-binding protein 2, and non-toxigenic Corynebacterium diphtheriae isolated from cases of pharyngitis.

Biochem./physiol. Wirkung

Wirkungsweise: Inhibiert die Synthese von Bakterienzellwänden.
Antimicrobielles Spektrum: Gram-positive Bakterien..

Verpackung

1 G, 5 G

Vorsicht

Solutions should be filter sterilized and stored at 2-8°C for 1 week or at -20°C for more lengthy periods. Solutions are stable at 37°C for 3 days. The sodium salt is soluble in H2O at 100 mg/mL.

Sonstige Hinweise

Keep container tightly closed in a dry and well-ventilated place. Product contains Penicillin.

Piktogramme

Exclamation mark
GHS07

Signalwort

Warning

H-Sätze

H317

Gefahreneinstufungen

Skin Sens. 1

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Analysenzertifikate (COA)

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C von Hunolstein et al.
The Journal of antimicrobial chemotherapy, 50(1), 125-128 (2002-07-04)
Twenty-four strains of non-toxigenic Corynebacterium diphtheriae biotype gravis from the throats of patients with pharyngitis/tonsillitis were assayed for susceptibility to penicillin and erythromycin using determination of MIC, MBC and time-kill curves. There were no differences between the MICs of penicillin
Paul P Drury et al.
Neuropharmacology, 83, 62-70 (2014-04-15)
Basal ganglia injury after hypoxia-ischemia remains common in preterm infants, and is closely associated with later cerebral palsy. In the present study we tested the hypothesis that a highly selective neuronal nitric oxide synthase (nNOS) inhibitor, JI-10, would improve survival
Susumu Ochiai et al.
The Journal of antimicrobial chemotherapy, 60(1), 54-60 (2007-06-02)
In Neisseria gonorrhoeae, the mosaic structure of penicillin-binding protein 2 (PBP 2), composed of fragments of PBP 2 from Neisseria cinerea and Neisseria perflava, was significantly associated with decreased susceptibility to cephalosporins, particularly oral cephalosporins. The aim of this study
Muneki Hotomi et al.
PloS one, 8(3), e58124-e58124 (2013-03-14)
The protection against pneumococcal infections provided by currently available pneumococcal polysaccharide conjugate vaccines are restricted to the limited number of the serotypes included in the vaccine. In the present study, we evaluated the distribution of the pneumococcal capsular type and
Shella Gilbert-Girard et al.
Microorganisms, 8(11) (2020-11-26)
In an effort to find new repurposed antibacterial compounds, we performed the screening of an FDA-approved compounds library against Staphylococcus aureus American Type Culture Collection (ATCC) 25923. Compounds were evaluated for their capacity to prevent both planktonic growth and biofilm
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Artikel

Inhibition of Cell Wall Biosynthesis by Antibiotics

β-lactam antibacterials inhibit transpeptidase enzymes, preventing peptidoglycan assembly in both Gram-positive and Gram-negative bacteria.

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