AB10029
Anti-Ubiquitylhiston H2A.X (Lys119)-Antikörper
serum, from rabbit
Synonym(e):
H2AXK119Ub, Histone H2A.X Ubiquityl K119), H2A histone family, member X, H2AX histone
Größe auswählen
| Packungsgröße | SKU | Verfügbarkeit | Preis |
|---|---|---|---|
| 100 μL | Warenkorb auf Verfügbarkeit prüfen | € 545,00 |
Über diesen Artikel
biological source
rabbit
Quality Segment
antibody form
serum
antibody product type
primary antibodies
clone
polyclonal
species reactivity
mouse, human
species reactivity (predicted by homology)
rat (based on 100% sequence homology), bovine (based on 100% sequence homology), canine (based on 100% sequence homology)
technique(s)
immunocytochemistry: suitable, immunoprecipitation (IP): suitable, western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
ubiquitination (Lys119)
Gene Information
bovine ... H2Ax(531733)
dog ... H2Ax(489372)
human ... H2AX(3014)
mouse ... H2Ax(15270)
rat ... H2Ax(500987)
General description
Immunogen
Application
Epigenetik & Zellkernfunktion
Histone
Analyse mittels Immunpräzipitation: 5 µg deiner repräsentativen Charge von immunpräzipiziertem Histon H2A.X in HeLa-Säureextrakt.
Biochem/physiol Actions
Physical form
Preparation Note
Analysis Note
HeLa-Säureextrakt
Western-Blot-Analyse: Eine 1:1.000 Verdünnung dieses Antikörpers wies Histone H2A.X in 10 µg HeLa-Säureextrakt nach.
Other Notes
Disclaimer
1 of 1
Dieser Artikel | |||
|---|---|---|---|
| biological source rabbit | biological source rabbit | biological source rabbit | biological source mouse |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| antibody form serum | antibody form affinity isolated antibody | antibody form affinity isolated antibody | antibody form purified immunoglobulin |
| Gene Information bovine ... H2Ax(531733) | Gene Information human ... H2AFX(3014) | Gene Information human ... Histone H2AX(3014) | Gene Information human ... H2AFX(3014) |
| technique(s) immunocytochemistry: suitable, western blot: suitable, immunoprecipitation (IP): suitable | technique(s) ELISA: 1:10000, immunohistochemistry: 1:50-1:100, western blot: 1:500-1:1000 | technique(s) ELISA: suitable (Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.), immunofluorescence: 1:50-1:200, immunohistochemistry: 1:50-1:200, western blot: 1:500-1:1000 | technique(s) immunofluorescence: suitable, indirect ELISA: suitable |
| shipped in wet ice | shipped in wet ice | shipped in wet ice | shipped in dry ice |
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Lagerklasse
10 - Combustible liquids
wgk
WGK 1
Analysenzertifikate (COA)
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Verwandter Inhalt
Cancer is a complex disease manifestation. At its core, it remains a disease of abnormal cellular proliferation and inappropriate gene expression. In the early days, carcinogenesis was viewed simply as resulting from a collection of genetic mutations that altered the gene expression of key oncogenic genes or tumor suppressor genes leading to uncontrolled growth and disease (Virani, S et al 2012). Today, however, research is showing that carcinogenesis results from the successive accumulation of heritable genetic and epigenetic changes. Moreover, the success in how we predict, treat and overcome cancer will likely involve not only understanding the consequences of direct genetic changes that can cause cancer, but also how the epigenetic and environmental changes cause cancer (Johnson C et al 2015; Waldmann T et al 2013). Epigenetics is the study of heritable gene expression as it relates to changes in DNA structure that are not tied to changes in DNA sequence but, instead, are tied to how the nucleic acid material is read or processed via the myriad of protein-protein, protein-nucleic acid, and nucleic acid-nucleic acid interactions that ultimately manifest themselves into a specific expression phenotype (Ngai SC et al 2012, Johnson C et al 2015). This review will discuss some of the principal aspects of epigenetic research and how they relate to our current understanding of carcinogenesis. Because epigenetics affects phenotype and changes in epigenetics are thought to be key to environmental adaptability and thus may in fact be reversed or manipulated, understanding the integration of experimental and epidemiologic science surrounding cancer and its many manifestations should lead to more effective cancer prognostics as well as treatments (Virani S et al 2012).
Global Trade Item Number
| SKU | GTIN |
|---|---|
| AB10029 | 04053252699856 |