422706

KN-62

A cell-permeable, reversible, and selective inhibitor of CaM kinase II (K_i = 900 nM for rat brain CaM kinase II) that binds directly to the calmodulin binding site of the enzyme.

• Synonym(e): KN-62, 1-[N,O- bis-(5-Isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperazine, P2X Antagonist II, Purinergic Receptor P2X Antagonist II, 1-[N,O-bis-(5-Isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperazine, P2X Antagonist II, Purinergic Receptor P2X Antagonist II
• Empirische Formel (Hill-System): C₃₈H₃₅N₅O₆S₂
• CAS-Nummer: 127191-97-3
• Molekulargewicht: 721.84
• UNSPSC Code: 12352200
• MDL number: MFCD00083180
• Assay: ≥95% (HPLC)
• Form: solid
• Storage condition: OK to freeze, desiccated, protect from light

Eigenschaften

• Quality Segment: 100
• assay: ≥95% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, desiccated, protect from light
• color: off-white
• solubility: methanol: 5 mg/mL, DMSO: soluble
• shipped in: ambient
• storage temp.: 2-8°C
• InChI: 1S/C38H35N5O6S2/c1-41(50(45,46)36-11-5-7-29-26-39-19-17-33(29)36)35(38(44)43-23-21-42(22-24-43)31-9-3-2-4-10-31)25-28-13-15-32(16-14-28)49-51(47,48)37-12-6-8-30-27-40-20-18-34(30)37/h2-20,26-27,35H,21-25H2,1H3
• InChI key: RJVLFQBBRSMWHX-UHFFFAOYSA-N

Beschreibung

General description

A cell-permeable, reversible, and selective inhibitor of Ca²⁺/calmodulin-dependent protein kinase II (K_i = 900 nM for rat brain enzyme) that binds directly to the calmodulin binding site of the enzyme. Also inhibits the growth of K562 cells in a dose-dependent manner.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
cam kinase 2

Product does not compete with ATP.

Reversible: yes

Target K_i: 900 nM for rat brain CaM kinase II

Preparation Note

Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 4 months at 4°C.

Further dilute with aqueous buffer just prior to use.

Other Notes

Minami, H., et al. 1994. Biochem. Biophys. Res. Commun.199, 241.
Kato, M., et al. 1992. Neurosci. Lett.129, 47.
Ishii, A., et al. 1991. Biochem. Biophys. Res. Commun.176, 1051.
Ito, I., et al. 1991. Neurosci. Lett.121, 119.
Tokumitsu, H., et al. 1990. J. Biol. Chem.265, 4315.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable