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Merck

1.08694

SAFC

Deviron® 13-S9

Detergent, EMPROVE® EXPERT

Arzneimittelherstellung

Synonym(e):

Alcohols, C11-15-secondary, ethoxylated

Anmeldenzur Ansicht organisationsspezifischer und vertraglich vereinbarter Preise


About This Item

Qualitätsniveau

Produktlinie

EMPROVE® EXPERT

Anwendung(en)

pharma/biopharma processes

Lagertemp.

15-25°C

Allgemeine Beschreibung

Detergents, such as non-ionic surfactants, are used in biomanufacturing processes for a variety of applications including viral inactivation and cell lysis. Detergent-mediated viral inactivation is widely used in multiple biotherapeutic production processes to ensure meeting regulatory requirements for viral safety.

Our SAFC portfolio of high-quality raw materials for use in biopharmaceutical processing withstands strict quality control procedures plus the documentation and expertise to help our customers meet requirements as defined by the M-Clarity Program.

M-Clarity Program

As part of our EMPROVE® Program, our raw materials are offered with EMPROVE® Dossiers which provide comprehensive, up-to-date documentation to help you navigate regulatory challenges, manage risks, and improve your manufacturing processes.

Our comprehensive portfolio of downstream process chemicals not only provides biopharmaceutical manufacturers with high-quality raw materials for production of classical and novel therapies, but also helps them get to market faster and simplify regulatory challenges. Ranging from non-GMP grades for low-risk application, to IPEC-PQG GMP for higher-risk applications, we have products covering all your manufacturing needs.

We offer a range of high quality critical raw materials plus the documentation and expertise to help our customers meet stringent regulatory requirements. Our SAFC portfolio of high-quality products withstands strict quality control procedures.

Anwendung

REACH compliantdetergent used in viral inactivation or cell lysis.

Verpackung

1.08694.1000 / 1L / Glass bottle

1.08694.2500 / 2.5L / Glass bottle

1.08694.9025 / 25L / PE container

Rechtliche Hinweise

DEVIRON is a registered trademark of Merck KGaA, Darmstadt, Germany
Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

Piktogramme

CorrosionExclamation mark

Signalwort

Danger

Gefahreneinstufungen

Acute Tox. 4 Oral - Aquatic Chronic 3 - Eye Dam. 1 - Skin Irrit. 2

Lagerklassenschlüssel

10 - Combustible liquids

WGK

WGK 1

Flammpunkt (°F)

469.4 °F - open cup

Flammpunkt (°C)

243 °C - open cup


Analysenzertifikate (COA)

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Artikel

Diese Seite beschreibt, welche zentralen Aspekte bei der Zelllyse zu berücksichtigen sind und wie die Kombination einer hohen Salzkonzentration mit einer salztoleranten Endonuklease zur Steigerung des Vektortiters und der Infektiosität bei der Herstellung von AAV-Vektoren eingesetzt werden kann.

This page describes key considerations for cell lysis and how the combination of a high salt concentration and a salt tolerant endonuclease can be used to increase vector titer and infectivity during AAV vector manufacturing.

Verwandter Inhalt

The use of Benzonase® endonuclease can significantly reduce the levels of DNA by more than 100,000-fold while also reducing viscosity and protecting downstream equipment from DNA fouling. However, optimization strategies and DoE are critical when it comes to reducing DNA in your process. Setting up a DoE for your Benzonase® endonuclease application can help you find the optimal operation conditions that deliver the required DNA clearance from your process.

Learn more on mAb downstream processing, more specifically virus inactivation and the relevant associated products.

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