Proceedings of the National Academy of Sciences of the United States of America, 117(34), 20848-20859 (2020-08-12)
Tuberculosis (TB) claims 1.5 million lives per year. This situation is largely due to the low efficacy of the only licensed TB vaccine, Bacillus Calmette-Guérin (BCG) against pulmonary TB. The metabolic disease type 2 diabetes (T2D) is a risk factor
Strains of Mycobacterium tuberculosis were divided into 'classical' and 'Asian' types according to their susceptibility to thiophen-2-carboxylic acid hydrazide (TCH). A study of 6638 new cases of tuberculosis showed that there was a much higher incidence of non-pulmonary disease among
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, 22(6), 661-666 (2018-06-05)
Phenotypic tests used to detect pyrazinamide (PZA) resistance are slow and have a high rate of false resistance. To evaluate the accuracy of pncA sequencing for the detection of PZA resistance in Mycobacterium tuberculosis strains isolated in Tunisia. A total
This study, conducted in Madras, India and in Madison, Wisconsin, USA, was concerned with the virulence of isolates of Mycobacterium tuberculosis obtained from the sputum of individuals living in the Chingleput district of south India. The following results were obtained.
Thiophen-2-carboxylic acid hydrazide (TCH) is used to distinguish TCH-sensitive bovine, 'Asian human' and 'African' strains from TCH-resistant 'classical' human strains of Mycobacterium tuberculosis. It has been claimed that this test cannot be applied to isoniazid-resistant strains as these also become
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