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I3377

Supelco

Isoniazid

analytical standard, ≥99% (TLC)

Synonym(e):

4-Pyridincarbonsäurehydrazid, INH, Isonicotinsäurehydrazid

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€ 16,50
50 G
€ 86,70
250 G
€ 171,00

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5 G
€ 16,50
50 G
€ 86,70
250 G
€ 171,00

About This Item

Empirische Formel (Hill-System):
C6H7N3O
CAS-Nummer:
54-85-3
Molekulargewicht:
137.14
Beilstein:
119374
EG-Nummer:
200-214-6
MDL-Nummer:
MFCD00006426
UNSPSC-Code:
41116107
PubChem Substanz-ID:
329815370
NACRES:
NA.24

€ 16,50

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Qualität

analytical standard

Qualitätsniveau

100

Assay

≥99% (TLC)

Methode(n)

HPLC: suitable
gas chromatography (GC): suitable

mp (Schmelzpunkt)

171-173 °C (lit.)

Fluoreszenz

λex 360 nm; λem 450 nm (thiol adduct)

Wirkungsspektrum von Antibiotika

mycobacteria

Anwendung(en)

forensics and toxicology
pharmaceutical (small molecule)

Format

neat

SMILES String

NNC(=O)c1ccncc1

InChI

1S/C6H7N3O/c7-9-6(10)5-1-3-8-4-2-5/h1-4H,7H2,(H,9,10)

InChIKey

QRXWMOHMRWLFEY-UHFFFAOYSA-N

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Allgemeine Beschreibung

Chemical structure: pyridine
Isoniazid is a type of drug possessing antimycobacterial activity.It is used in the treatment of tuberculosis.[1]

Anwendung

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem./physiol. Wirkung

Antibiotikum für die Behandlung von Mycobacterium tuberculosis; inhibiert die Mycolsäure-Biosynthese. Wird von hepatischer N-Acetyltransferase (NAT) und Cytochrom P450 2E1 (CYP2E1) zu Hepatotoxinen metabolisert. Induziert selektiv die Expression von CYP2E1. Inhibiert Aktivitäten von CYP2C19 und CYP3A4 reversibel und inaktiviert CYP1A2, CYP2A6, CYP2C19 und CYP3A4 bei klinisch relevanten Konzentrationen.

Empfohlene Produkte

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Piktogramme

Exclamation mark
GHS07

Signalwort

Warning

H-Sätze

H302,H315

Gefahreneinstufungen

Acute Tox. 4 Oral - Skin Irrit. 2

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Gloves

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number
0000376808
MKCW1792
0000376808
MKCT7593
0000241662

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Die Dokumentenbibliothek aufrufen

Ram Shankar Upadhayaya et al.
European journal of medicinal chemistry, 45(5), 1854-1867 (2010-02-09)
We have designed and synthesized both the quinoline and naphthalene based molecules influenced by the unique structural make-up of mefloquine and TMC207, respectively. These compounds were evaluated for their anti-mycobacterial activity against drug sensitive Mycobacterium tuberculosis H37Rv in vitro at
Isoniazid could be used for antibiotic-loaded bone cement for musculoskeletal tuberculosis: an in vitro study
Han DC, et al.
Clinical Orthopaedics and Related Research, 471(7), 2400-2406 (2013)
Samantha Ellis et al.
Molecular pharmacology, 85(2), 269-278 (2013-11-19)
The rise in drug-resistant strains of Mycobacterium tuberculosis is a major threat to human health and highlights the need for new therapeutic strategies. In this study, we have assessed whether high-affinity iron chelators of the pyridoxal isonicotinoyl hydrazone (PIH) class
Molebogeng X Rangaka et al.
Lancet (London, England), 384(9944), 682-690 (2014-05-20)
Antiretroviral therapy reduces the risk of tuberculosis, but tuberculosis is more common in people with HIV than in people without HIV. We aimed to assess the effect of isoniazid preventive therapy on the risk of tuberculosis in people infected with
Anandi Martin et al.
The Journal of antimicrobial chemotherapy, 62(1), 56-64 (2008-04-15)
The reference standard methods for drug susceptibility testing (DST) of M. tuberculosis are very slow to give results, and due to the emergence of multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis, there is an urgent demand for new, rapid and
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Questions

1–3 of 3 Questions  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  3. How do I prepare a 10mL solution of the drug at a concentration of 10mg/mL

    1 answer

    1. 100 mg of material would need to be dissolved in 10 total mL of solvent. Solubility is tested at 50 mg/mL in water, so water is suitable at this concentration. It should also be soluble in ethanol up to 20 mg/mL or so, but this is not tested or guaranteed by us. Please keep in mind that this is an R&D-grade material intended for use as an analytical standard - not for use as a drug for human or animal application.

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