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Merck

N33101

Sigma-Aldrich

Norharman

98%

Synonym(e):

β-Carboline, 9H-Pyrido[3,4-b]indole

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About This Item

Empirische Formel (Hill-System):
C11H8N2
CAS-Nummer:
Molekulargewicht:
168.19
MDL-Nummer:
UNSPSC-Code:
12352202
PubChem Substanz-ID:

Assay

98%

SMILES String

c1ccc2c(c1)[nH]c3cnccc23

InChI

1S/C11H8N2/c1-2-4-10-8(3-1)9-5-6-12-7-11(9)13-10/h1-7,13H

InChIKey

AIFRHYZBTHREPW-UHFFFAOYSA-N

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Biochem./physiol. Wirkung

Inhibitor of indoleamine 2,3-dioxygenase (IDO).

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Hashem Haghdoost-Yazdi et al.
Behavioural brain research, 215(1), 136-140 (2010-07-20)
beta-Carbolines (BCs) are considered as endogenous neurotoxins that may contribute to the pathogenesis of Parkinson's disease (PD). However, several lines of evidences show that these compounds have neuroprotective effect. This study was designed to assess effect of long term exposure
Caiping Tan et al.
Dalton transactions (Cambridge, England : 2003), 40(34), 8611-8621 (2011-08-02)
Three novel Ru(II) complexes of the general formula [Ru(N-N)(2)(Norharman)(2)](SO(3)CF(3))(2), where N-N = 2,2'-bipyridine (bpy, 1), 1,10-phenanthroline (phen, 2), 4,7-diphenyl-1,10-phenanthroline (DIP, 3) and Norharman (9H-pyrido[3,4-b]indole) is a naturally occurring β-carboline alkaloid, have been synthesized and characterized. The molecular structures of 1
Ute Jautz et al.
Journal of agricultural and food chemistry, 56(12), 4311-4319 (2008-05-29)
A recently developed HPTLC/UV-FLD method was compared to the routinely used HPLC/UV-FLD method for the quantification of heterocyclic aromatic amines (HAA) formed at trace levels during the heating process of meat. For formation of these process contaminants under normal cooking
Tomás Herraiz et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 49(8), 1773-1781 (2011-05-11)
Monoamine oxidase (MAO) enzymes located in human mitochondria oxidize neurotransmitters and bioactivate the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) by oxidation to directly-acting neurotoxic pyridinium cations (MPDP⁺/MPP⁺) that produce Parkinsonism. Antioxidants and MAO inhibitors are useful as neuroprotectants. Naturally-occurring substances, antioxidants and redox
Antônio Eduardo Miller Crotti et al.
Molecular nutrition & food research, 54(3), 433-439 (2009-10-14)
The beta-carbolines 1-methyl-9H-pyrido [3,4-b]indole and 9H-pyrido[3,4b]indole have been implicated as having causative roles in a number of human diseases, such as Parkinson's disease and cancer. As they can be formed during the heating of protein-rich food, a number of analytical

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