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103276
Harman
98%
Synonym(e):
1-Methyl-9H-pyrido[3,4-b]-indol, 2-Methyl-β-carbolin, Aribin
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Über diesen Artikel
Quality Segment
assay
98%
drug control
stupéfiant (France)
mp
235-238 °C (lit.)
solubility
methanol: soluble 50mg/ml
SMILES string
Cc1nccc2c3ccccc3[nH]c12
InChI
1S/C12H10N2/c1-8-12-10(6-7-13-8)9-4-2-3-5-11(9)14-12/h2-7,14H,1H3
InChI key
PSFDQSOCUJVVGF-UHFFFAOYSA-N
Gene Information
human ... CYP2D6(1565)
rat ... Gabra2(29706)
General description
- Harmane is a potent tremor-producing β-carboline alkaloid and neurotoxin.
- It is major representative of heterocyclic aromatic amines, a group of mutagenic and carcinogenic substances which are formed in meat from the precursors creatine, creatinine, amino acids and sugars during the heating at high temperatures.
- Blood harmane concentration is elevated in essential tremor, late-life neurological disease.
Application
- Harmane was used in trace level determination of harmane by planar chromatography coupled with (tandem) mass spectrometry.
- It was used to study interactions of norharman and harman with DNA.
- It may be used as matrix for analysis of cyclodextrins and for sulfated oligosaccharides in combination with DHB as co-matrix.
Biochem/physiol Actions
Preparation Note
1 of 1
Dieser Artikel | ||
|---|---|---|
| description 98% | description analytical standard | description ≥95% |
| assay 98% | assay ≥97.0% (HPLC) | assay ≥95% |
| solubility methanol: soluble 50mg/ml | solubility - | solubility - |
| Quality Level 100 | Quality Level 100 | Quality Level 100 |
| mp 235-238 °C (lit.) | mp 235-238 °C | mp 232-234 °C (lit.) |
| drug control stupéfiant (France) | drug control - | drug control regulated under CDSA - not available from Sigma-Aldrich Canada, stupéfiant (France); regulated under CDSA - not available from Sigma-Aldrich Canada |
| Gene Information human ... CYP2D6(1565) | Gene Information - | Gene Information human ... ADRA1A(148), ADRA1B(147), ADRA2A(150), ADRA2B(151), ADRA2C(152), ADRB1(153), ADRB2(154), CHRM1(1128), CHRM2(1129), CHRM3(1131), CHRM4(1132), CHRM5(1133), DRD1(1812), DRD5(1816), HTR1A(3350), HTR1B(3351), HTR1D(3352), HTR2C(3358), HTR3A(3359), HTR5A(3361), HTR6(3362), HTR7(3363), SLC6A2(6530), SLC6A4(6532), SLC9A2(6549), SLC9A5(6553) |
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Signalwort
Warning
Gefahrencodes
Sicherheitshinweise
Hazard Classifications
Acute Tox. 4 Oral - Skin Irrit. 2
Lagerklasse
11 - Combustible Solids
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
PSA (Persönliche Schutzausrüstung)
Eyeshields, Gloves, type N95 (US)
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