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Sigma-Aldrich

Quinacrin -dihydrochlorid

98%

Synonym(e):

6-Chlor-9-(4-diethylamino-1-methylbutylamino)-2-methoxy-acridin -dihydrochlorid, Atebrin -dihydrochlorid, Mepacrin -dihydrochlorid, Quinacrin -dihydrochlorid

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About This Item

Empirische Formel (Hill-System):
C23H30ClN3O · 2HCl
CAS-Nummer:
69-05-6
Molekulargewicht:
472.88
Beilstein:
4834013
EG-Nummer:
200-700-8
MDL-Nummer:
MFCD00012659
UNSPSC-Code:
12352200

Assay

98%

SMILES String

Cl[H].Cl[H].CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc3ccc(OC)cc13

InChI

1S/C23H30ClN3O.2ClH/c1-5-27(6-2)13-7-8-16(3)25-23-19-11-9-17(24)14-22(19)26-21-12-10-18(28-4)15-20(21)23;;/h9-12,14-16H,5-8,13H2,1-4H3,(H,25,26);2*1H

InChIKey

UDKVBVICMUEIKS-UHFFFAOYSA-N

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Biochem./physiol. Wirkung

Non-selective MAO-A/B inhibitor.

Piktogramme

Exclamation mark
GHS07

Signalwort

Warning

H-Sätze

H302

Gefahreneinstufungen

Acute Tox. 4 Oral

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Gloves

Analysenzertifikate (COA)

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Tingting Gu et al.
Biosensors & bioelectronics, 33(1), 222-227 (2012-02-07)
A novel strategy of amperometric assay for drug-dsDNA interactions was developed based on an inhibitory effect of antimararial drug (quinacrine) on an electrocatalytic activity of DNA-Cu(II) complex. In this method, a DNA-Cu(II) complex immobilized DNA/polyallylamine(PAA) polyion complex membrane was used
Sarah Chahine et al.
Archives of insect biochemistry and physiology, 81(4), 228-240 (2012-09-14)
An earlier study has shown that RNAi knock-down of a single organic anion transporter (OAT) gene in the principal cells of Drosophila Malpighian tubules is associated with reductions in the expression of multiple, functionally related genes. In this study, we
Misol Ahn et al.
PloS one, 7(7), e39112-e39112 (2012-07-07)
The lipophilic cationic compound quinacrine has been used as an antimalarial drug for over 75 years but its pharmacokinetic profile is limited. Here, we report on the pharmacokinetic properties of quinacrine in mice. Following an oral dose of 40 mg/kg/day
Jifeng Bian et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(16), 6028-6033 (2014-04-09)
Quinacrine's ability to reduce levels of pathogenic prion protein (PrP(Sc)) in mouse cells infected with experimentally adapted prions led to several unsuccessful clinical studies in patients with prion diseases, a 10-y investment to understand its mechanism of action, and the
Ranjan Preet et al.
Carcinogenesis, 34(2), 277-286 (2012-11-07)
We previously reported that quinacrine (QC) has anticancer activity against breast cancer cells. Here, we examine the mechanism of action of QC and its ability to inhibit Wnt-TCF signaling in two independent breast cancer cell lines. QC altered Wnt-TCF signaling
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