901579

t-Boc-N-amido-PEG₁-CH₂CO₂H

• Fórmula empírica (notación de Hill): C₉H₁₇NO₅
• Número de CAS: 142929-49-5
• Peso molecular: 219.23
• MDL number: MFCD09909935
• UNSPSC Code: 51171641
• NACRES: NA.22

Propiedades

• form: liquid
• reaction suitability: reagent type: cross-linking reagent
• functional group: Boc; amine; carboxylic acid
• storage temp.: −20°C
• SMILES string: O=C(O)COCCNC(OC(C)(C)C)=O
• InChI: 1S/C9H17NO5/c1-9(2,3)15-8(13)10-4-5-14-6-7(11)12/h4-6H2,1-3H3,(H,10,13)(H,11,12)
• InChI key: UPBQMAHYLWJGDW-UHFFFAOYSA-N

Descripción

Application

This is a crosslinker with a t-Boc protected amine on one end and a carboxyl group on the other end. The compound contains a single PEG unit to help improve solubility

t-Boc-N-amido-PEG₁-CH₂CO₂H is a heterobifunctional, PEGylated crosslinker featuring a Boc-protected amine at one end and a carboxyl group at the other. The hydrophillic PEG linker facilitates solubility in biological applications. t-Boc-N-amido-PEG₁-CH₂CO₂H can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC^® molecules) for targeted protein degradation.

Legal Information

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Información de seguridad

• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 3