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SML1862

TP-472

≥98% (HPLC)

Synonym(s):

3-(6-Acetyl-pyrrolo[1,2-a]pyrimidin-8-yl)-N-cyclopropyl-4-methyl-benzamide

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About This Item

Empirical Formula (Hill Notation):
C20H19N3O2
CAS Number:
Molecular Weight:
333.38
UNSPSC Code:
51111800
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
Quality level:


Quality Level

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 10 mg/mL, clear

storage temp.

2-8°C

SMILES string

O=C(C)C1=CC(C2=C(C)C=CC(C(NC3CC3)=O)=C2)=C4N=CC=CN41

InChI

1S/C20H19N3O2/c1-12-4-5-14(20(25)22-15-6-7-15)10-16(12)17-11-18(13(2)24)23-9-3-8-21-19(17)23/h3-5,8-11,15H,6-7H2,1-2H3,(H,22,25)

InChI key

RPBMXJHQYJLPDN-UHFFFAOYSA-N

Biochem/physiol Actions

Bromodomain BRD9/7 Probe
TP-472 is a selective probe for bromodomain-containing proteins BRD9 and BRD7. This BRD9/7 probe was developed out of a collaborative effort by Takeda and the SGC, and is of a different chemotype from BRD9/7 probes previously available. TP-472 has a KD value of 33nM for BRD9 and 340nM for BRD7 by ITC. It is >30 fold selective for BRD9 over all other bromodomain family members except BRD7. It is suitable for in vivo applications. For full characterization details, please visit the TP-472 probe summary on the Structural Genomics Consortium (SGC) website.

TP-472N is used as a negative control and is available from Sigma. To learn more about and purchase TP-472N, click here.

To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc

Features and Benefits

TP-472 is an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC
This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

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Show Differences

1 of 1

This Item
SML1933SML1355SML0333
assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

form

powder

form

powder

form

powder

form

powder

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

solubility

DMSO: 10 mg/mL, clear

solubility

DMSO: 15 mg/mL, clear

solubility

DMSO: 5 mg/mL, clear (warmed)

solubility

DMSO: 2 mg/mL, clear

color

white to beige

color

white to beige

color

yellow to orange

color

white to beige


Storage Class

11 - Combustible Solids

wgk

WGK 3



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Articles

We offer a variety of small molecule research tools, such as transcription factor modulators, inhibitors of chromatin modifying enzymes, and agonists/antagonists for target identification and validation in gene regulation research; a selection of these research tools is shown below.





Global Trade Item Number

SKUGTIN
SML1862-25MG04061832826233
SML1862-5MG04061832826240

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