T5425

Transforming Growth Factor-β3 human

≥97% (SDS-PAGE), recombinant, expressed in baculovirus infected Sf21 cells, powder, suitable for cell culture

• 同義詞: hTGF-β3, TGF-β3
• MDL號碼: MFCD00213054
• 分類程式碼代碼: 12352202
• NACRES: NA.77

屬性

• 產品名稱: Transforming Growth Factor-β3 human, TGF-β3, recombinant, expressed in baculovirus infected Sf21 cells, powder, suitable for cell culture
• 生物源: human
• 品質等級: 100
• 重組細胞: expressed in baculovirus infected Sf21 cells
• 化驗: ≥97% (SDS-PAGE)
• 形狀: powder
• 效力: 0.01-0.09 ng/mL ED₅₀/EC₅₀
• 品質: endotoxin tested
• 分子量: predicted mol wt ~25 kDa
• 包裝: pkg of 2 μg
• 儲存條件: avoid repeated freeze/thaw cycles
• 技術: cell culture | mammalian: suitable
• 雜質: <0.01 EU/μg
• UniProt登錄號: P10600
• 儲存溫度: −20°C
• 基因資訊: human ... TGFB3(7043)

描述

一般說明

The TGFβ3 (transforming Growth Factor-β3) gene is mapped to human chromosome 14q24.3.[1]

應用

Transforming Growth Factor-β3 human has been used to study the role of TGF-β3 in healing tendon-to-bone insertion and in chondrogenic differentiation.[2][3]

生化／生理作用

TGF-β (transforming growth factor-β3) isoforms are significantly involved in inducing inflammatory responses. It is associated with vascular diseases, wound healing and ameliorating effect in venous leg ulcer. TGF-β3 has an antagonistic effect on TGF-β1 and reduces the degree of collagen type I deposition and fibroblast differentiation. As a result TGF-β3 might lead to ulcer chronicity due to hindered myofibroblasts formation.[4] TGF-β is a key player in tumor formation and progression. Increased TGF-β3 expression is observed in cancer and adipose tissue fibrosis.[5][6] TGF-β3 is crucial in tissue regeneration and scarless tissue repair.[7]

TGF-β3 is less prevalent in natural expression than either TGF-β1 or TGF-β2, but it is the most abundant mRNA expressed in chick embryos. It is also expressed in human umbilical cord, in a variety of mesenchymal cells of human and rodent origin, and in several human carcinoma cells.

外觀

Lyophilized from a 0.2 μm filtered solution in 35% acetonitrile and 0.1% trifluoroacetic acid containing 50 μg bovine serum albumin per 1 μg of cytokine.

分析報告

The biological activity is measured by its ability to inhibit the IL-4-dependent proliferation of mouse HT-2 cells.

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: Eyeshields, Gloves, type N95 (US)