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重要文件

A4544

Sigma-Aldrich

L -抗坏血酸

suitable for cell culture, suitable for plant cell culture, ≥98%

同義詞:

维他命C, 抗坏血病因子, 维生素C

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About This Item

經驗公式(希爾表示法):
C6H8O6
CAS號碼:
分子量::
176.12
Beilstein:
84272
EC號碼:
MDL號碼:
分類程式碼代碼:
12352201
PubChem物質ID:
NACRES:
NA.21
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品質等級

化驗

≥98%

形狀

powder

分子量

Mw 176.12 g/mol

技術

cell culture | mammalian: suitable
cell culture | plant: suitable

顏色

white to light yellow

pH值

1.0-2.5 (25 °C, 176 g/L in water)

mp

190-194 °C (dec.)

溶解度

water: soluble 50 mg/mL

SMILES 字串

OC([C@]([C@@H](O)CO)([H])O1)=C(O)C1=O

InChI

1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/t2-,5+/m0/s1

InChI 密鑰

CIWBSHSKHKDKBQ-JLAZNSOCSA-N

基因資訊

human ... SLC23A2(9962)

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一般說明

L-抗坏血酸又称为维生素C,是一种水溶性维生素,在各种生化反应中起还原剂的作用。抗坏血酸在胶原的合成中起到关键作用。抗坏血酸对神经发育、神经递质合成和调节神经元突触至关重要。[1]膳食维生素C缺乏会对认知能力有负面影响。[2]

應用

L-抗坏血酸已被用作牛乳腺上皮细胞[3] 和卵母细胞-颗粒细胞复合物基础培养基的成分。[4]它已被用作成骨培养基中成骨分化的补充物。[5][6]

生化/生理作用

抗坏血酸,也称为维生素C,是由植物和一些动物物种产生的六碳内酯,但人类和其他灵长类动物不能产生。抗坏血酸作为多种酶的酶促辅助因子发挥作用,用作单加氧酶和双加氧酶的电子供体。抗坏血酸也是一种强大的抗氧化剂,尤其是对活性氧类。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 1

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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分析證明 (COA)

Lot/Batch Number

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存取文件庫

Mitochondrial dysfunction of in vitro grown rabbit oocytes results in preimplantation embryo arrest after activation
Kanaya H, et al.
Journal of Reproduction and Development, 53(3), 631-637 (2007)
The effect of mesenchymal stromal cells on the osseoinduction of impaction grafts
Korda M, et al.
Tissue Engineering: Part A, 16(2), 675-683 (2009)
Multipotency and cardiomyogenic potential of human adipose-derived stem cells from epicardium, pericardium, and omentum
Wystrychowski W, et al.
Stem Cell Research & Therapy, 7(1), 84-84 (2016)
Vitamin C status and cognitive function: A systematic review
Travica N, et al.
Nutrients, 9(9), 960-960 (2017)
Does vitamin C deficiency affect cognitive development and function?
Hansen SN, et al.
Nutrients, 6(9), 3818-3846 (2014)

文章

Importance and uses of ascorbate in serum-free eukaryotic, including hybridoma and Chinese Hamster Ovary (CHO) cell, cultures

Questions

1–3 of 3 Questions  
  1. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  2. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  3. Can we store vitamin C solution (25mM) at -20 degree? In case for how many time it can be stored?

    1 answer
    1. The solution stability of this compound has not been determined, however it is subject to degradation when exposted to oxygen or alkaline pH conditions. As a general rule, avoid repeated freeze/thaw cycles. The publication below indicates that the material is stable when stored frozen in RPMI-1640 at -20°C.
      https://pubmed.ncbi.nlm.nih.gov/1698293/

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