跳轉至內容
Merck
全部照片(1)

文件

S6951

Sigma-Aldrich

Surfen水合物

≥98% (HPLC)

同義詞:

1,3-二（4-氨基-2-甲基-6-喹啉）脲水合物, NSC 12155, N，N′-双（4-氨基-2-甲基-6-喹啉）脲, 二-2-甲基-4-氨基喹啉-6-脲水合物, 双氨甲喹脲, 氨喹脲, 氨基尿苷

登入查看組織和合約定價
全部照片(1)

About This Item

經驗公式（希爾表示法）:
C21H20N6O · xH2O
CAS號碼:
1241801-02-4
分子量：:
372.42 (anhydrous basis)
MDL號碼:
MFCD17215963
分類程式碼代碼:
12352200
PubChem物質ID:
329824572
NACRES:
NA.77

品質等級

100

化驗

≥98% (HPLC)

形狀

powder

顏色

white to beige

溶解度

DMSO: 2 mg/mL, clear

儲存溫度

2-8°C

SMILES 字串

O.Cc1cc(N)c2cc(NC(=O)Nc3ccc4nc(C)cc(N)c4c3)ccc2n1

InChI

1S/C21H20N6O.H2O/c1-11-7-17(22)15-9-13(3-5-19(15)24-11)26-21(28)27-14-4-6-20-16(10-14)18(23)8-12(2)25-20;/h3-10H,1-2H3,(H2,22,24)(H2,23,25)(H2,26,27,28);1H2

InChI 密鑰

UXYZYUHSZVKWTR-UHFFFAOYSA-N

應用

Surfen水合物可用作肝素的拮抗剂。
Surfen水合物已用于抑制人类胚胎肾细胞中的多个电压门控钙通道。

生化／生理作用

Surfen是一种硫酸乙酰肝素拮抗剂，最初于三十年代后期开发，作为生产长效胰岛素的赋形剂。 硫酸乙酰肝素（HS）在结构上与肝素相关，但每个二糖含有较少的硫酸根基团，并且几乎仅存在于蛋白聚糖的蛋白核心上，蛋白聚糖在质膜上显示或分泌到细胞外基质中。Surfen与糖胺聚糖（GAG）/HS的链结合并阻止酶和蛋白质的结合，从而充当HS拮抗剂。 Surfen比鱼精蛋白（一种临床使用的肝素拮抗剂）更有效。

危險聲明

H413

防範說明

P273 - P501

危險分類

Aquatic Chronic 4

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

分析證明 (COA)

輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。

已經擁有該產品？

您可以在文件庫中找到最近購買的產品相關文件。

存取文件庫

Carl W White et al.
iScience, 24(1), 102011-102011 (2021-01-26)
Secreted chemokines are critical mediators of cellular communication that elicit intracellular signaling by binding membrane-bound receptors. Here we demonstrate the development and use of a sensitive real-time approach to quantify secretion and receptor binding of native chemokines in live cells
Sapthaswaran Veerapathiran et al.
eLife, 9 (2020-11-26)
Wnt3 proteins are lipidated and glycosylated signaling molecules that play an important role in zebrafish neural patterning and brain development. However, the transport mechanism of lipid-modified Wnts through the hydrophilic extracellular environment for long-range action remains unresolved. Here we determine
Elodie Monsellier et al.
PloS one, 15(8), e0237328-e0237328 (2020-08-14)
α-Synuclein (αSyn) fibrils spread from one neuronal cell to another. This prion-like phenomenon is believed to contribute to the progression of the pathology in Parkinson's disease and other synucleinopathies. The binding of αSyn fibrils originating from affected cells to the
urfen is a broad-spectrum calcium channel inhibitor with analgesic properties in mouse models of acute and chronic inflammatory pain
Rivas-Ramirez P, et al.
Pflugers Archiv : European Journal of Physiology, 469, 1325-1334 (2017)
Christian Kirschneck et al.
International journal of molecular sciences, 21(24) (2020-12-19)
Orthodontic tooth movement (OTM) creates compressive and tensile strain in the periodontal ligament, causing circulation disorders. Hypoxia-inducible factor 1α (HIF-1α) has been shown to be primarily stabilised by compression, but not hypoxia in periodontal ligament fibroblasts (PDLF) during mechanical strain
查看所有相關論文

我們的科學家團隊在所有研究領域都有豐富的經驗，包括生命科學、材料科學、化學合成、色譜、分析等.

聯絡技術服務