跳轉至內容
Merck
全部照片(1)

重要文件

H8891

Sigma-Aldrich

肝素酶III 来源于肝素黄杆菌

Lyophilized powder stabilized with approx. 25% (w/w) bovine serum albumin, ≥30 units/mg protein (enzyme + BSA)

同義詞:

肝素裂解酶III, 肝素酶 来源于肝素黄杆菌, 肝素酶I

登入查看組織和合約定價


About This Item

CAS號碼:
酶委員會編號:
MDL號碼:
分類程式碼代碼:
12352204
NACRES:
NA.54
暫時無法取得訂價和供貨情況

生物源

bacterial (Flavobacterium heparinum)

品質等級

共軛

conjugate (Glucosaminoglycan)

形狀

lyophilized powder

比活性

≥30 units/mg protein (enzyme + BSA)

分子量

70.8 kDa

應用

diagnostic assay manufacturing

儲存溫度

−20°C

尋找類似的產品? 前往 產品比較指南

應用

肝素黄杆菌肝素酶III已用于裂解特定GAG。[1][2]已用于研究其对与抗aFGF(酸性成纤维细胞生长因子)抗体反应的蛋白质的电泳迁移率的影响。[3]

生化/生理作用

肝素酶III可防止体内新血管的形成。[4]它在HNY-I和HNY、6X-G2连接处特异性降解硫酸肝素。与其他肝素酶不同,肝素酶III不含氨基酸半胱氨酸。它含有13个组氨酸残基,这是其催化作用的原因。[5]该酶对肝素或低分子量肝素没有活性。
肝素降解裂解酶,识别硫酸肝素蛋白聚糖为其主要底物。

單位定義

在25 °C、pH 7.5条件下,一个单位每小时可形成0.1 μM不饱和糖醛酸。一个国际单位(I.U.)相当于大约600个Sigma单位。包装规格基于Sigma单位。

象形圖

Health hazard

訊號詞

Danger

危險聲明

防範說明

危險分類

Resp. Sens. 1

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


從最近期的版本中選擇一個:

分析證明 (COA)

Lot/Batch Number

未看到正確版本?

如果您需要一個特定的版本,您可以透過批號來尋找特定憑證。

已經擁有該產品?

您可以在文件庫中找到最近購買的產品相關文件。

存取文件庫

Fluid shear stress primes mouse embryonic stem cells for differentiation in a self-renewing environment via heparan sulfate proteoglycans transduction
Toh YC and Voldman J
Faseb Journal, 25(4), 1208-1217 (2011)
FGF binding by extracellular matrix components of Wharton's jelly
Malkowski A, et al.
Acta Biochimica Polonica, 54(2), 357-357 (2007)
Erin M Smith et al.
Proceedings of the National Academy of Sciences of the United States of America, 106(51), 21683-21688 (2009-12-08)
Platelet-derived growth factor (PDGF) signaling is essential for processes involving cell motility and differentiation during embryonic development in a wide variety of organisms including the mouse, frog, zebrafish, and sea urchin. In early Xenopus laevis embryos, PDGF-AA provides guidance cues
Composition of the endothelial glycocalyx and its relation to its thickness and diffusion of small solutes
Gao L and Lipowsky HH
Microvascular Research, 80(3), 394-401 (2010)
A Constantinescu et al.
Thrombosis and haemostasis, 105(5), 790-801 (2010-12-22)
A thick endothelial glycocalyx contributes to the barrier function of vascular endothelium in macro- and microcirculation. We hypothesised in the current study that diet-induced hyperlipidaemia perturbs the glycocalyx, resulting in decreased dimensions of this layer and increased transendothelial lipoprotein leakage

文章

Uncover more about glycosaminoglycans and proteoglycans including the structure of glycosaminoglycans (GAGs), the different types of GAGs, and their functions.

瞭解更多關於糖胺聚醣和蛋白質聚醣的資訊,包括糖胺聚醣 (GAG) 的結構、不同類型的 GAG 及其功能。

Glycosaminoglycans are large linear polysaccharides constructed of repeating disaccharide units.

Questions

1–3 of 3 Questions  
  1. Does Product No. H8891, Heparinase III, contain calcium?

    1 answer
    1. This product is lyophilized from a solution which is 75 mM NaCl/ 5mM NaH2PO4. We have no reason to believe that calcium ions are present.

      Helpful?

  2. Is Product No. H8891, Heparinase III sold based on Sigma Units or International Units?

    1 answer
    1. This material is sold based on Sigma Units.  One Sigma Unit will form 0.1 μmole of unsaturated uronic acid per hr at pH 7.5 at 25 °C. One International Unit (I.U.) is equivalent to approx. 600 Sigma units.

      Helpful?

  3. What is the Department of Transportation shipping information for this product?

    1 answer
    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

      Helpful?

Reviews

No rating value

Active Filters

我們的科學家團隊在所有研究領域都有豐富的經驗,包括生命科學、材料科學、化學合成、色譜、分析等.

聯絡技術服務