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S3256

Sigma-Aldrich

精胺

≥97%

同義詞:

N,N′-双(3-氨基丙基)-1,4-丁二胺, 精素, 肌胺, 肝胺

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About This Item

線性公式:
NH2(CH2)3NH(CH2)4NH(CH2)3NH2
CAS號碼:
71-44-3
分子量：:
202.34
Beilstein:
1750791
EC號碼:
200-754-2
MDL號碼:
MFCD00008215
分類程式碼代碼:
12352116
PubChem物質ID:
24899550
NACRES:
NA.25
暫時無法取得訂價和供貨情況

生物源

microbial
synthetic

品質等級

200

描述

form: solid or semisolid

化驗

≥97%

bp

150 °C/5 mmHg (lit.)

mp

28-30 (lit.)

溶解度

water: 50 mg/mL, clear, colorless

儲存溫度

2-8°C

SMILES 字串

[H]N(CCCN)CCCCN([H])CCCN

InChI

1S/C10H26N4/c11-5-3-9-13-7-1-2-8-14-10-4-6-12/h13-14H,1-12H2

InChI 密鑰

PFNFFQXMRSDOHW-UHFFFAOYSA-N

基因資訊

human ... GRIN2B(2904)
rat ... Grin2a(24409)

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一般說明

精胺是一种多胺，可用作自由基清除剂。它可调节基因表达、稳定染色质、以及防止DNA损伤。精胺可抑制内切核酸酶介导的DNA片段化。[1]

應用

精胺已被用于：
  • 作为肌醇1,4,5-三磷酸酯受体（IP3R）/葡萄糖调节蛋白75（Grp75）/电压依赖性阴离子通道1（VDAC1）/线粒体钙单向转运蛋白（MCU）的激动剂，以激活小鼠足细胞中的MCU[2]
  • 丝虫寄生虫的基因枪转染中[3]
  • 生产腺相关病毒（AAV）[4]

生化／生理作用

多胺位点混合型 NMDA 受体激动剂/拮抗剂。在细胞增殖和分化中发挥作用；抑制神经元一氧化氮合成酶 (nNOS)。
多胺位点混合型 NMDA 谷氨酸受体激动剂/拮抗剂。在高浓度 (1mM) 下观察到神经保护作用，而在低浓度下则观察到神经毒性。它在番木鳖碱-不敏感性甘氨酸位点能够增强激动剂效应。在细胞增殖和分化中发挥作用；抑制神经元一氧化氮合成酶 (nNOS)。

象形圖

Corrosion
GHS05

訊號詞

Danger

危險聲明

H314

危險分類

Eye Dam. 1 - Skin Corr. 1B

儲存類別代碼

8A - Combustible corrosive hazardous materials

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

從最近期的版本中選擇一個：

分析證明 (COA)

Lot/Batch Number
BCCL3738
BCCM1182
BCCK5792
BCCJ7415
BCCL1254

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存取文件庫

IP 3 R-Grp75-VDAC1-MCU calcium regulation axis antagonists protect podocytes from apoptosis and decrease proteinuria in an Adriamycin nephropathy rat model
Xu H, et al.
BMC Nephrology, 19(1), 140-140 (2018)
Brugia malayi: transient transfection by microinjection and particle bombardment
Higazi TB, et al.
Experimental Parasitology, 100(2), 95-102 (2002)
H C Ha et al.
Proceedings of the National Academy of Sciences of the United States of America, 95(19), 11140-11145 (1998-09-16)
The polyamines are small organic cations that are absolutely required for eukaryotic cell growth. Although their growth requirements are well established, the molecular functions of the polyamines are ill-defined. Oxidative damage to DNA by reactive oxygen species is a continual
Using mammalian GFP reconstitution across synaptic partners (mGRASP) to map synaptic connectivity in the mouse brain.
Feng L, et al.
Nature Protocols, 9(10), 2425-2425 (2014)
Lydia P P Liew et al.
Bioorganic & medicinal chemistry letters, 23(2), 452-454 (2012-12-26)
Screening of synthesized and isolated marine natural products for in vitro activity against four parasitic protozoa has identified the ascidian metabolite 1,14-sperminedihomovanillamide (orthidine F, 1) as being a non-toxic, moderate growth inhibitor of Plasmodium falciparum (IC(50) 0.89 μM). Preliminary structure-activity
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文章

Sensor Dyes

Nitric oxide (NO) as a signal transporter in neurons, endothelial cells and in the immune system.

感应染料

一氧化氮 (NO) 是神经元、内皮细胞和免疫系统中的信号转运分子。

Questions

1–3 of 3 Questions  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  3. What is the storage temperature for the product?

    1 answer

    1. As mentioned in the PROPERTIES section of the product detail page, the storage temperature of the product is 2-8°C.

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