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R0654

Sigma-Aldrich

Reveromycin A

solid, suitable for cell culture, BioReagent

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About This Item

經驗公式（希爾表示法）:
C36H52O11
CAS號碼:
134615-37-5
分子量：:
660.79
MDL號碼:
MFCD00912537
分類程式碼代碼:
12352207
PubChem物質ID:
24899342
NACRES:
NA.76
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產品名稱

Reveromycin A, solid

生物源

Streptomyces sp.

品質等級

200

形狀

solid

分子量

660.79 g/mol

包裝

pkg of 100 μg

顏色

tan

溶解度

DMF: soluble
DMSO: soluble
ethanol: soluble
ethyl acetate: soluble
methanol: soluble
soluble

抗生素活性譜

fungi

作用方式

protein synthesis | interferes

運輸包裝

wet ice

儲存溫度

−20°C

SMILES 字串

[H][C@]1(C\C=C(C)\C=C\[C@H](O)[C@@H](C)\C=C\C(O)=O)O[C@]2(CC[C@@H]1C)CC[C@@](CCCC)(OC(=O)CCC(O)=O)[C@@]([H])(O2)\C=C\C(C)=C\C(O)=O

InChI

1S/C36H52O11/c1-6-7-19-35(47-34(44)17-16-32(40)41)21-22-36(46-30(35)14-10-25(3)23-33(42)43)20-18-27(5)29(45-36)13-9-24(2)8-12-28(37)26(4)11-15-31(38)39/h8-12,14-15,23,26-30,37H,6-7,13,16-22H2,1-5H3,(H,38,39)(H,40,41)(H,42,43)/b12-8+,14-10+,15-11+,24-9+,25-23+/t26-,27-,28-,29+,30-,35+,36-/m0/s1

InChI 密鑰

ZESGNAJSBDILTB-OXVOKJAASA-N

生化／生理作用

It is an epidermal growth factor (EGF) and eukaryotic cell growth inhibitor.[1][2]
Reveromycin A is a polyketide antibiotic from Streptomyces sp. Epidermal growth factor (EGF) inhibitor; apoptosis inducer; G1 phase cell cycle inhibitor having antiproliferative behavior against human cell lines KB and K562 as well as antifungal activity.

分析報告

Avoid acidic conditions.

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

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分析證明 (COA)

Lot/Batch Number
SLCN4843
SLCP1231
SLBN9570V
SLBM8028V
SLBL5566V

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Hiroyuki Osada
Current medicinal chemistry, 10(9), 727-732 (2003-04-08)
In this review, I have mainly described the cell cycle inhibitors isolated from microbial metabolites. Once the molecular target of the inhibitor is determined, the inhibitor can be used as bioprobe to dissect the diverse aspect of biological functions in
Naoyuki Takahashi et al.
Odontology, 95(1), 1-9 (2007-07-31)
Osteoclast function consists of several processes: recognition of mineralized tissues, development of ruffled borders and sealing zones, secretion of acids and proteolytic enzymes into the space beneath the ruffled border, and incorporation and secretion of bone degradation products using the
Saburo Sone et al.
Cancer metastasis reviews, 26(3-4), 685-689 (2007-09-06)
Bone metastasis is a critical problem of lung cancer patients. Reproducible animal models of lung cancer bone metastasis, like NK-cell depleted SCID mouse model with SCB-5 cells, are useful to explore the molecular mechanism and search of molecular targets. SBC-5
T Shimizu et al.
Organic letters, 2(14), 2153-2156 (2000-07-13)
The stereoselective total synthesis of reveromycin A (1), a potent inhibitor of eukaryotic cell growth, has been accomplished on the basis of the stereocontrolled construction of the 6,6-spiroketal system, efficient succinylation of the tert-alcohol under high pressure, and the introduction
Takeshi Shimizu et al.
Bioorganic & medicinal chemistry letters, 18(13), 3756-3760 (2008-06-04)
Various derivatives of reveromycin A, an inhibitor of eukaryotic cell growth, and spirofungin A, focusing on the 5S hydroxyl group and C18 hemisuccinyl group, were synthesized and their inhibitory effects on both the isoleucyl-tRNA synthetase activity and the survival of
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