推薦產品
檢測方法
colorimetric
相關疾病
neurological disorders
儲存溫度
−20°C
基因資訊
human ... SDHA(6389) , SDHAF1(644096) , SDHAF2(54949) , SDHB(6390) , SDHC(6391) , SDHD(6392)
mouse ... SDHA(66945) , SDHAF1(68332) , SDHAF2(66072) , SDHB(67680) , SDHC(66052) , SDHD(66925)
rat ... SDHA(157074) , SDHAF2(361726) , SDHB(298596) , SDHC(289217) , SDHD(363061)
一般說明
琥珀酸脱氢酶（SDH；酶代码 EC 1.3.5.1）是一种线粒体酶，在真核生物和细菌中催化琥珀酸氧化为延胡索酸，并携带电子从 FADH 到 CoQ。在通过三羧酸循环和电子传递链维持细胞能量代谢中起中心作用。SDH 突变引起遗传性副神经节瘤/嗜铬细胞瘤综合征和一种被称为 Leigh 综合征的神经退行性疾病。
適合性
本试剂盒适于检测不同生物样品（如细胞、组织培养上清液和纯化的线粒体）中琥珀酰脱氢酶的活性。
原則
琥珀酸脱氢酶活性比色检测试剂盒为测定多种组织、细胞和分离线粒体中的 SDH 活性提供了一种简单、灵敏的程序。通过产生与存在的酶活性成比例的 600nm 吸光度的产物来确定 SDH 活性。一个单位的 SDH 是在 pH7.2，25℃ 下每分钟产生 1.0μmole DCIP 的酶量。
僅套裝組件
產品號碼
描述
- SDH Assay Buffer
- SDH Substrate Mix
- SDH Probe
- DCIP Standard, 2 mM
- SDH Positive Control
儲存類別代碼
10 - Combustible liquids
從最近期的版本中選擇一個：
分析證明 (COA)
Lot/Batch Number
Liu Ze et al.
Human vaccines & immunotherapeutics, 15(2), 388-396 (2018-10-10)
Rabies is the most lethal zoonotic, vaccine-preventable viral disease in the world. Its treatment is complicated by insufficient vaccine supply and the requirement for four to five repeated injections, as commercially available inactivated rabies lack adjuvant and have low immunogenicity.
Brian P Daniels et al.
Immunity, 50(1), 64-76 (2019-01-13)
As long-lived post-mitotic cells, neurons employ unique strategies to resist pathogen infection while preserving cellular function. Here, using a murine model of Zika virus (ZIKV) infection, we identified an innate immune pathway that restricts ZIKV replication in neurons and is
Mohammad Golam Sabbir et al.
Cell communication and signaling : CCS, 19(1), 98-98 (2021-09-27)
The calcium (Ca2+)/calmodulin (CAM)-activated kinase kinase 2 (CAMKK2)-signaling regulates several physiological processes, for example, glucose metabolism and energy homeostasis, underlying the pathogenesis of metabolic diseases. CAMKK2 exerts its biological function through several downstream kinases, therefore, it is expected that depending
Microbial Siderophore Enterobactin Promotes Mitochondrial Iron Uptake and Development of the Host via Interaction with ATP Synthase.
Qi B and Han M
Cell (2018)
Hossein Maghsoudi et al.
Clinical rheumatology, 37(9), 2471-2478 (2018-04-18)
Osteoarthritis (OA) is a chronic degenerative joint disease with inflammatory component. It is associated with progressive histological alterations and disabling symptoms. Today, drugs such as glucocorticoids (GCs) and nonsteroidal anti-inflammatory drugs (NSIADs) are commonly employed for treatment of osteoarthritis, but
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