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MAK197

Sigma-Aldrich

琥珀酸脱氢酶检测试剂盒

Sufficient for 100 Colorimetric tests

同義詞:

SDH活性检测试剂盒

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About This Item

分類程式碼代碼:
12161503
NACRES:
NA.84
暫時無法取得訂價和供貨情況

檢測方法

colorimetric

相關疾病

neurological disorders

儲存溫度

−20°C

基因資訊

human ... SDHA(6389) , SDHAF1(644096) , SDHAF2(54949) , SDHB(6390) , SDHC(6391) , SDHD(6392)
mouse ... SDHA(66945) , SDHAF1(68332) , SDHAF2(66072) , SDHB(67680) , SDHC(66052) , SDHD(66925)
rat ... SDHA(157074) , SDHAF2(361726) , SDHB(298596) , SDHC(289217) , SDHD(363061)

一般說明

琥珀酸脱氢酶（SDH；酶代码 EC 1.3.5.1）是一种线粒体酶，在真核生物和细菌中催化琥珀酸氧化为延胡索酸，并携带电子从 FADH 到 CoQ。在通过三羧酸循环和电子传递链维持细胞能量代谢中起中心作用。SDH 突变引起遗传性副神经节瘤/嗜铬细胞瘤综合征和一种被称为 Leigh 综合征的神经退行性疾病。

應用

琥珀酸脱氢酶活性比色测定试剂盒已用于测定样品中琥珀酸脱氢酶的酶活性。[1][2]

適合性

本试剂盒适于检测不同生物样品（如细胞、组织培养上清液和纯化的线粒体）中琥珀酰脱氢酶的活性。

原則

琥珀酸脱氢酶活性比色检测试剂盒为测定多种组织、细胞和分离线粒体中的 SDH 活性提供了一种简单、灵敏的程序。通过产生与存在的酶活性成比例的 600nm 吸光度的产物来确定 SDH 活性。一个单位的 SDH 是在 pH7.2，25℃ 下每分钟产生 1.0μmole DCIP 的酶量。

僅套裝組件

產品號碼
描述
  • SDH Assay Buffer
  • SDH Substrate Mix
  • SDH Probe
  • DCIP Standard, 2 mM
  • SDH Positive Control

取代透過

產品號碼
描述
訂價

儲存類別代碼

10 - Combustible liquids

從最近期的版本中選擇一個：

分析證明 (COA)

Lot/Batch Number
8E18K06600
8A14K06600
7C11K06600
6G23K06600
6B06K06600

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Growth of ovarian cancer xenografts causes loss of muscle and bone mass: a new model for the study of cancer cachexia.
Pin F, et al.
Journal of Cachexia, Sarcopenia and Muscle, 9(4), 685-700 (2018)
Brian P Daniels et al.
Immunity, 50(1), 64-76 (2019-01-13)
As long-lived post-mitotic cells, neurons employ unique strategies to resist pathogen infection while preserving cellular function. Here, using a murine model of Zika virus (ZIKV) infection, we identified an innate immune pathway that restricts ZIKV replication in neurons and is
Mohammad Golam Sabbir et al.
Cell communication and signaling : CCS, 19(1), 98-98 (2021-09-27)
The calcium (Ca2+)/calmodulin (CAM)-activated kinase kinase 2 (CAMKK2)-signaling regulates several physiological processes, for example, glucose metabolism and energy homeostasis, underlying the pathogenesis of metabolic diseases. CAMKK2 exerts its biological function through several downstream kinases, therefore, it is expected that depending
Fabrizio Pin et al.
Journal of cachexia, sarcopenia and muscle, 9(4), 685-700 (2018-07-17)
Cachexia frequently occurs in women with advanced ovarian cancer (OC), along with enhanced inflammation. Despite being responsible for one third of all cancer deaths, cachexia is generally under-studied in OC due to a limited number of pre-clinical animal models. We
Liu Ze et al.
Human vaccines & immunotherapeutics, 15(2), 388-396 (2018-10-10)
Rabies is the most lethal zoonotic, vaccine-preventable viral disease in the world. Its treatment is complicated by insufficient vaccine supply and the requirement for four to five repeated injections, as commercially available inactivated rabies lack adjuvant and have low immunogenicity.
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  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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