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M7316

Sigma-Aldrich

单胺氧化酶A 人

recombinant, expressed in baculovirus infected BTI insect cells

同義詞:

MAO-A, MAOA

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About This Item

酶委員會編號:
MDL號碼:
分類程式碼代碼:
12352204
NACRES:
NA.54

重組細胞

expressed in baculovirus infected BTI insect cells

品質等級

形狀

liquid

包裝

vial of ~2.5 mg

UniProt登錄號

運輸包裝

dry ice

儲存溫度

−70°C

基因資訊

human ... MAOA(4128)

一般說明

单胺氧化酶A含有8α-S-半胱氨酰-FAD的结合位点。
单胺氧化酶可对中枢神经系统和外周组织中的生物胺进行代谢。

應用

单胺氧化酶A已被用于评估具有单胺氧化酶A酶活性不足的大批男性的异常行为。 它也被用于研究调查吸烟与抑制MAOA之间的关联。

生化/生理作用

MAO是一种线粒体膜蛋白。 这些酶负责催化内生和异生胺的氧化脱氨。 每种同工酶的底物特异性不同。

儲存類別代碼

12 - Non Combustible Liquids

水污染物質分類(WGK)

WGK 1

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)


分析證明 (COA)

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J S Fowler et al.
Proceedings of the National Academy of Sciences of the United States of America, 93(24), 14065-14069 (1996-11-26)
Several studies have documented a strong association between smoking and depression. Because cigarette smoke has been reported to inhibit monoamine oxidase (MAO) A in vitro and in animals and because MAO A inhibitors are effective antidepressants, we tested the hypothesis
Ryuichi Harada et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 62(2), 253-258 (2020-07-11)
Reactive astrocytes play a key role in the pathogenesis of various neurodegenerative diseases. Monoamine oxidase-B (MAO-B) is one of the promising targets for the imaging of astrogliosis in the human brain. A novel selective and reversible MAO-B tracer, (S)-(2-methylpyrid-5-yl)-6-[(3-18F-fluoro-2-hydroxy)propoxy]quinoline (18F-SMBT-1)
Marcus A Maher et al.
Analytical and bioanalytical chemistry, 408(3), 695-703 (2015-11-18)
The need for rapid and cost-effective pre-screening protocols of the toxicological response of the vast array of emerging nanoparticle types is apparent and the emerging consensus on the paradigm of oxidative stress by generation of intracellular reactive oxygen species as
Wenping Wang et al.
Antioxidants (Basel, Switzerland), 10(10) (2021-10-24)
Neurotransmitter catecholamines (dopamine, epinephrine, and norepinephrine) are liable to undergo oxidation, which copper is deeply involved in. Catecholamine oxidation-derived neurotoxicity is recognized as a pivotal pathological mechanism in neurodegenerative diseases. Glutamate, as an excitatory neurotransmitter, is enriched in the brain
Dale E Edmondson et al.
Neurotoxicology, 25(1-2), 63-72 (2003-12-31)
The structural details of the interactions of the covalent 8alpha-S-cysteinyl-FAD with the protein moiety in monoamine oxidase B (MAO B) based on the MAO B crystal structure are described. The dinucleotide is bound to the protein in an extended conformation

文章

Serotonin is stored in cells and metabolized by MAO, influencing CNS, GI, and platelet functions.

血清素儲存在細胞中,並經 MAO 代謝,影響中樞神經系統、消化道和血小板功能。

我們的科學家團隊在所有研究領域都有豐富的經驗,包括生命科學、材料科學、化學合成、色譜、分析等.

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