推薦產品
產品名稱
Mdivi-1, ≥98% (HPLC), powder
化驗
≥98% (HPLC)
形狀
powder
顏色
white to beige
溶解度
DMSO: >20 mg/mL
運輸包裝
wet ice
儲存溫度
−20°C
SMILES 字串
COc1cc(N2C(S)=Nc3ccccc3C2=O)c(Cl)cc1Cl
InChI
1S/C15H10Cl2N2O2S/c1-21-13-7-12(9(16)6-10(13)17)19-14(20)8-4-2-3-5-11(8)18-15(19)22/h2-7H,1H3,(H,18,22)
InChI 密鑰
NZJKEVWTYMOYOR-UHFFFAOYSA-N
生化／生理作用
Mdivi-1是线粒体DRP（发动蛋白相关GTP酶）分裂选择性抑制剂以及线粒体分裂发动蛋白（Dnm1）抑制剂。线粒体融合和分裂在细胞凋亡调节中有很重要的作用。Mdivi-1是线粒体分裂发动蛋白首选抑制剂。基本上，Mdivi-1代表了一系列用于治疗中风，心肌梗塞和神经退行性疾病的药物。
Mdivi-1是线粒体DRP（发动蛋白相关GTP酶）分裂选择性抑制剂；线粒体分裂发动蛋白（Dnm1）抑制剂。
特點和優勢
该化合物是细胞凋亡研究的特色产品。点击此处 ，查看更多细胞凋亡精选产品。想要了解有关生物活性小分子在其他研究领域应用的更多信息，请访问sigma.com/discover-bsm。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
從最近期的版本中選擇一個：
分析證明 (COA)
Lot/Batch Number
客戶也查看了
To mdivi-1 or not to mdivi-1: Is that the question?
Smith G and Gallo G
Developmental neurobiology, 77(11), 1260-1268 (2017)
Da Zhang et al.
PloS one, 13(5), e0197266-e0197266 (2018-05-17)
Hypoxia-mediated pancreatic beta cell death is one of the main causes of pancreatic beta celldeath, which leads to the loss of functional pancreatic beta cell mass and type 1 diabetes andtype 2 diabetes.However, the molecular mechanisms that control life and
The putative Drp1 inhibitor mdivi-1 is a reversible mitochondrial complex I inhibitor that modulates reactive oxygen species
Bordt EA, et al.
Developmental Cell, 40(6), 583-594 (2017)
Impaired mitophagy leads to cigarette smoke stress-induced cellular senescence: implications for chronic obstructive pulmonary disease
Ahmad T, et al.
Faseb Journal, 29(7), 2912-2929 (2015)
Jia Sun et al.
The Journal of endocrinology (2019-01-09)
The molecular signaling mechanisms of Coenzyme Q10 (CoQ10) in diabetic nephropathy (DN) remain poorly understood. We verified that mitochondrial abnormalities, like defective mitophagy, the generation of mitochondrial reactive oxygen species (mtROS) and the reduction of mitochondrial membrane potential, occurred in
文章
Cell cycle phases (G1, S, G2, M) regulate cell growth, DNA replication, and division in proliferating cells.
Apoptosis regulation involves multiple pathways and molecules for cellular homeostasis.
Active Filters
我們的科學家團隊在所有研究領域都有豐富的經驗，包括生命科學、材料科學、化學合成、色譜、分析等.
聯絡技術服務
