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Merck
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文件

I6504

Sigma-Aldrich

(−)-Isoproterenol hydrochloride

≥98% (TLC), powder, β-adrenoceptor agonist

同義詞:

(-)-异丙去甲肾上腺素 盐酸盐

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About This Item

線性公式:
3,4-(HO)2C6H3CH(OH)CH2NHCH(CH3)2·HCl
CAS號碼:
分子量::
247.72
Beilstein:
6077193
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77

product name

(−)-Isoproterenol hydrochloride,

mp

175 °C (dec.) (lit.)

溶解度

soluble (50 mg/ml: H2O)

儲存溫度

−20°C

SMILES 字串

Cl[H].CC(C)NC[C@H](O)c1ccc(O)c(O)c1

InChI

1S/C11H17NO3.ClH/c1-7(2)12-6-11(15)8-3-4-9(13)10(14)5-8;/h3-5,7,11-15H,6H2,1-2H3;1H/t11-;/m0./s1

InChI 密鑰

IROWCYIEJAOFOW-MERQFXBCSA-N

基因資訊

human ... ADRB2(154)

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應用

(−)-Isoproterenol hydrochloride has been used in in vitro explant culture. It has also been used in transcriptome analysis of heart.

生化/生理作用

Isoproterenol hydrochloride is useful in post transplantal organ recovery. It exhibits ionotropic and chronotropic effects. With respect to donor heart recovery, isoproterenol hydrochloride decreases peripheral and systemic vascular resistance. Isoproterenol also increases the heart rate.
β-adrenoceptor agonist; increases cytosolic cAMP.

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


分析證明 (COA)

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Anne-Marie Schönegge et al.
Nature communications, 8(1), 2169-2169 (2017-12-20)
Functional selectivity of G-protein-coupled receptors is believed to originate from ligand-specific conformations that activate only subsets of signaling effectors. In this study, to identify molecular motifs playing important roles in transducing ligand binding into distinct signaling responses, we combined in
Acute Care Handbook for Physical Therapists, 414-414 (2008)
Michael H Lai et al.
American journal of physiology. Heart and circulatory physiology, 307(9), H1327-H1338 (2014-08-31)
Large-conductance Ca(2+)- and voltage-activated K(+) (BK) channels play prominent roles in shaping muscle and neuronal excitability. In the cardiovascular system, BK channels promote vascular relaxation and protect against ischemic injury. Recently, inhibition of BK channels has been shown to lower
Seon Jin Lee et al.
Stem cells international, 2018, 7453161-7453161 (2018-12-05)
Cross talks between the renin-angiotensin system (RAS), sympathetic nervous system, and vascular homeostasis are tightly coordinated in hypertension. Angiotensin II (Ang II), a key factor in RAS, when abnormally activated, affects the number and bioactivity of circulating human endothelial progenitor
Influence of adipocyte size and adipose depot on the in vitro lipolytic activity and insulin sensitivity of adipose tissue in dairy cows at the end of the dry period
De Koster J, et al.
Journal of Dairy Science, 99(3), 2319-2328 (2016)

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